TUBB - tubulin beta class I Gene

Also Known as M40; TUBB1; TUBB5; CDCBM6; CSCSC1; OK/SW-cl.56

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 203068

About TUBB

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,720,352-30,725,422 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 271 orthologues, 23 paralogues and is associated with 5 phenotypes. Ubiquitous expression in ovary (RPKM 250.9), bone marrow (RPKM 212.6) and 25 other tissues.

Summary

This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with Other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]

TUBB Products (6)

mRNA	Protein	Name
NM_001293212.2	NP_001280141.1	tubulin beta chain isoform a
NM_001293213.2	NP_001280142.1	tubulin beta chain isoform c
NM_001293214.2	NP_001280143.1	tubulin beta chain isoform d
NM_001293215.2	NP_001280144.1	tubulin beta chain isoform e
NM_001293216.2	NP_001280145.1	tubulin beta chain isoform e
NM_178014.4	NP_821133.1	tubulin beta chain isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables MHC class I protein binding	IDA IDA: Inferred from direct assay	11120798	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16049941	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21753002	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23178297	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
located in microtubule	IDA IDA: Inferred from direct assay	21525035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TUBB Protein Structure

Tubulin

Tubulin_C

0
100
200
300
400
444 a.a.

Protein Preferred Names	Protein Names
tubulin beta chain	beta Ib tubulin

TUBB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TUBB	P07437	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	TUBB	P07437	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	TUBB	P07437	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	TUBB	P07437	TUBA1A	Homo sapiens	Q71U36	Anti Tag CoIP	33961781
Intra	TUBB	P07437	TUBA1A	Homo sapiens	Q71U36	BiFC	30274285
Intra	TUBB	P07437	SQSTM1	Homo sapiens	Q13501	Validated Y2H	32814053
Intra	TUBB	P07437	SQSTM1	Homo sapiens	Q13501	Y2H Pooling	32814053
Intra	TUBB	P07437	SQSTM1	Homo sapiens	Q13501	Y2H Array	32814053
Intra	TUBB	P07437	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	33961781
Intra	TUBB	P07437	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
Intra	TUBB	P07437	DLST	Homo sapiens	P36957	Validated Y2H	32814053
Intra	TUBB	P07437	DLST	Homo sapiens	P36957	Y2H Array	32814053
Intra	TUBB	P07437	MAPT	Homo sapiens	P10636-8	BiFC	30274285
Intra	TUBB	P07437	TFF2	Homo sapiens	Q03403	Validated Y2H	32814053
Intra	TUBB	P07437	TFF2	Homo sapiens	Q03403	Y2H Array	32814053
Intra	TUBB	P07437	TFF2	Homo sapiens	Q03403	Y2H Pooling	32814053
Intra	TUBB	P07437	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	TUBB	P07437	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	TUBB	P07437	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	TUBB	P07437	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	24275654
Intra	TUBB	P07437	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
Intra	TUBB	P07437	FXR1	Homo sapiens	P51114	Anti Tag CoIP	21653829
Intra	TUBB	P07437	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	TUBB	P07437	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	TUBB	P07437	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	TUBB	P07437	NEDD8	Homo sapiens	Q15843	Y2H Array	32814053
Intra	TUBB	P07437	NEDD8	Homo sapiens	Q15843	Validated Y2H	32814053
Intra	TUBB	P07437	NEDD8	Homo sapiens	Q15843	Y2H Pooling	32814053
Intra	TUBB	P07437	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
Intra	TUBB	P07437	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
Intra	TUBB	P07437	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	TUBB	P07437	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	TUBB	P07437	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Cross	TUBB	P07437	EBNA-LP	Epstein-Barr virus	Q8AZK7	Anti Bait CoIP	18457437

Cross: Cross-species interaction Intra: Intraspecies interaction

TUBB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80955	Beta Tubulin Antibody (YA839)	WB, ICC/IF	Human, Mouse, Monkey, Goat, Hamster, Rat, Chlamydomonas Reinhardtii
HY-P80955A	Beta Tubulin Antibody (HRP) (YA865)	WB	Human, Mouse, Monkey, Hamster, Rat
HY-P83991	Beta Tubulin Antibody (YA3688)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P83991A	Beta Tubulin Antibody (YA3688)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P85805	Beta Tubulin Antibody (YA5497)	WB, ICC/IF, ELISA	Human, Mouse, Rat, Pig

Related Diseases

Diseases	Alias
Cortical Dysplasia, Complex, With Other Brain Malformations 6	Complex Cortical Dysplasia With Other Brain Malformations 6 CDCBM6 Cdcbm56 Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6
Skin Creases, Congenital Symmetric Circumferential, 1	Michelin Tire Baby Syndrome CSCSC1 Skin Creases, Multiple Benign Ring-Shaped, Of Limbs Circumferential Skin Creases, Kunze Type Congenital Symmetric Circumferential Skin Creases 1 Circumferential Skin Creases Kunze Type Symmetric Circumferential Skin Creases, Congenital, 1 Csc-Kt Multiple Benign Ring-Shaped Skin Creases Of Limbs Michelin-Tire Baby
Multiple Benign Circumferential Skin Creases On Limbs	Ccsf Circumferential Skin Creases, Kunze Type Congenital Circumferential Skin Folds Kunze-Riehm Syndrome Kunze Riehm Syndrome Michelin Tire Baby Syndrome
Tubulin, Beta
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Hydrocephalus, Congenital, 1	Hydrocephaly Ventriculomegaly Hydrocephalus, Nonsyndromic, Autosomal Recessive 1 HYC1 Congenital Non-Communicating Hydrocephalus Hydrocephalus, Nonsyndromic, Autosomal Recessive 1, Formerly Congenital Obstructive Hydrocephalus Hydrocephalus, Non-Syndromic, Autosomal Recessive 1 Hydrocephalus
Skin Creases, Congenital Symmetric Circumferential, 2	CSCSC2 Symmetric Circumferential Skin Creases, Congenital, 2 Congenital Symmetric Circumferential Skin Creases 2
Cerebral Amyloid Angiopathy, Itm2b-Related, 1	Dementia, Familial British Fbd Presenile Dementia With Spastic Ataxia Familial British Dementia Abri Amyloidosis Cerebral Amyloid Angiopathy, British Type Itm2b-Related Cerebral Amyloid Angiopathy 1 Familial Dementia, British Type Cerebral Amyloid Angiopathy, Itm2b-Related 1 CAA-ITM2B1 Cerebral Amyloid Angiopathy British Type Dementia, Familial, British
Charcot-Marie-Tooth Disease, Axonal, Type 2k	Charcot-Marie-Tooth Disease Axonal Type 2k CMT2K Autosomal Recessive Charcot-Marie-Tooth Disease With Hoarseness Arcmt2k Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2k Autosomal Recessive Axonal Cmt4c4 Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2k Charcot-Marie-Tooth Neuropathy, Axonal, Type 2k Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2k Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Disease Type 2k Charcot-Marie-Tooth Neuropathy Axonal Type 2k Autosomal Dominant Charcot-Marie-Tooth Disease Type 2k Charcot-Marie-Tooth Disease 2k Charcot-Marie-Tooth Disease Neuronal Type 2k Charcot-Marie-Tooth Neuropathy Type 2k Charcot-Marie-Tooth Disease, Type 2k
Cerebellar Hypoplasia
Polymicrogyria	Pmg
Tubulinopathy	Tubulinopathies
Ganglioglioma	Childhood Ganglioglioma Adult Ganglioglioma Cns Ganglioglioma Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Axonal Neuropathy
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Neurofibromatosis-Noonan Syndrome	NFNS Neurofibromatosis Type 1 Neurofibromatosis With Noonan Phenotype Nf1 Von Recklinghausen Disease Neurofibromatosis Type 1-Noonan Syndrome Noonan Neurofibromatosis Syndrome Recklinghausen'S Disease Noonan-Neurofibromatosis Syndrome Fibromatosis Multiple Non Ossifying Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots Jaffe Campanacci Syndrome Type 1 Neurofibromatosis Neurofibromatosis 1 Peripheral Neurofibromatosis Recklinghausen Disease, Nerve Jaffe-Campanacci Syndrome
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Congenital Fibrosis Of The Extraocular Muscles	Congenital Fibrosis Of Extraocular Muscles Cfeom Feom Congenital External Ophthalmoplegia Congenital Fibrosis Syndrome General Fibrosis Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158208	PMMB276	Inhibitor	97.26%	Unkown
HY-RS15256	TUBB4B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-158208A	(1S)-PMMB276	Control	/	Unkown
HY-RS15254	TUBB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15250	TUBB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15251	TUBB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15252	TUBB2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15253	TUBB2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15255	TUBB4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15257	TUBB6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15258	TUBB8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19491	Tubb3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20612	Tubb4a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21214	Tubb4b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22888	Tubb6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25985	Tubb3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27120	Tubb4a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27730	Tubb4b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29402	Tubb6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TUBB	VGNC	VGNC:66699
Canis familiaris	TUBB	VGNC	VGNC:110552
Bos taurus	TUBB	VGNC	VGNC:103058
Rattus norvegicus	TUBB	RGD	RGD:628596
Macaca mulatta	TUBB	VGNC	VGNC:104438
Mus musculus	TUBB	MGD	MGI:107812
Others	TUBB	NCBI