DL-β-Hydroxybutyryl coenzyme A lithium

Name: DL-β-Hydroxybutyryl coenzyme A lithium
Brand: MedChemExpress
SKU: HY-134426
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Cat. No.: HY-134426 Pureza: 98.02%: Ficha de datos
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DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase.

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DL-β-Hydroxybutyryl coenzyme A lithium Estructura química

No. CAS : 103404-51-9

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	Obtener un presupuesto
10 mg	Obtener un presupuesto

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Other Forms of DL-β-Hydroxybutyryl coenzyme A lithium:

3-Hydroxybutyryl-CoA Obtener un presupuesto

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Human Endogenous Metabolite Microbial Metabolite

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Descripciòn

In Vitro

DL-β-Hydroxybutyryl coenzyme A lithium (β-Hydroxybutyryl-CoA) can be produced as an intermediate metabolite via the mitochondrial pathway, where impaired mitochondrial function in cancer cells leads to the accumulation of it. At the same time, DL-β-Hydroxybutyryl coenzyme A lithium can also be produced via the fatty acid β-oxidation, which is accelerated by starvation and fasting, leading to the accumulation of it and thus to diseases caused by certain metabolic adaptations^[1].
DL-β-Hydroxybutyryl coenzyme A lithium (β-Hydroxybutyryl-CoA) can act as a cofactor for lysine β-hydroxybutyrylation (Kbhb), with elevated levels of histone Kbhb in a streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) mouse model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fòrmula

C₂₅H₄₂Li₃N₇O₁₈P₃S

No. CAS

103404-51-9

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSC(CC(C)O)=O)=O)=O)O)C)=O)=O)O3.[Li].[Li].[Li]

Peso molecular

874.45

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

H2O : 50 mg/mL (57.18 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1436 mL	5.7179 mL	11.4358 mL
5 mM	0.2287 mL	1.1436 mL	2.2872 mL
10 mM	0.1144 mL	0.5718 mL	1.1436 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 98.02%

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Ficha de datos (271 KB) SDS (252 KB)

COA (248 KB) RP-HPLC (263 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kevin B Koronowski, et al. Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation. Cell Rep. 2021 Aug 3;36(5):109487. [Content Brief]

[2]. Zhongyu Xie, et al. Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. Mol Cell. 2016 Apr 21;62(2):194-206. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	1.1436 mL	5.7179 mL	11.4358 mL	28.5894 mL
	5 mM	0.2287 mL	1.1436 mL	2.2872 mL	5.7179 mL
	10 mM	0.1144 mL	0.5718 mL	1.1436 mL	2.8589 mL
	15 mM	0.0762 mL	0.3812 mL	0.7624 mL	1.9060 mL
	20 mM	0.0572 mL	0.2859 mL	0.5718 mL	1.4295 mL
	25 mM	0.0457 mL	0.2287 mL	0.4574 mL	1.1436 mL
	30 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.9530 mL
	40 mM	0.0286 mL	0.1429 mL	0.2859 mL	0.7147 mL
	50 mM	0.0229 mL	0.1144 mL	0.2287 mL	0.5718 mL