DL-β-Hydroxybutyryl coenzyme A lithium 

DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase^[1][2].

DL-β-Hydroxybutyryl coenzyme A lithium (β-Hydroxybutyryl-CoA) can be produced as an intermediate metabolite via the mitochondrial pathway, where impaired mitochondrial function in cancer cells leads to the accumulation of it. At the same time, DL-β-Hydroxybutyryl coenzyme A lithium can also be produced via the fatty acid β-oxidation, which is accelerated by starvation and fasting, leading to the accumulation of it and thus to diseases caused by certain metabolic adaptations^[1].
DL-β-Hydroxybutyryl coenzyme A lithium (β-Hydroxybutyryl-CoA) can act as a cofactor for lysine β-hydroxybutyrylation (Kbhb), with elevated levels of histone Kbhb in a streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) mouse model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

874.45

C₂₅H₄₂Li₃N₇O₁₈P₃S

103404-51-9

Solid

White to off-white

O=C(CCNC([C@H](O)C(C)(C)COP(OP(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@]([H])(N2C=NC3=C(N)N=CN=C32)O1)(O)=O)(O)=O)=O)NCCSC(CC(C)O)=O.[Li].[Li].[Li]

Room temperature in continental US; may vary elsewhere.

• [1]. Kevin B Koronowski, et al. Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation. Cell Rep. 2021 Aug 3;36(5):109487.  [Content Brief]

  [2]. Zhongyu Xie, et al. Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. Mol Cell. 2016 Apr 21;62(2):194-206.  [Content Brief]