DL-β-Hydroxybutyryl coenzyme A lithium
Based on 1 Customer Validation
DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase.
For research use only. We do not sell to patients.
- Purity: 98.02%
- CAS No.: 103404-51-9
- Formula: C25H42Li3N7O18P3S
- Molecular Weight:874.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
DL-β-Hydroxybutyryl coenzyme A lithium (β-Hydroxybutyryl-CoA) can be produced as an intermediate metabolite via the mitochondrial pathway, where impaired mitochondrial function in cancer cells leads to the accumulation of it. At the same time, DL-β-Hydroxybutyryl coenzyme A lithium can also be produced via the fatty acid β-oxidation, which is accelerated by starvation and fasting, leading to the accumulation of it and thus to diseases caused by certain metabolic adaptations[1].
DL-β-Hydroxybutyryl coenzyme A lithium (β-Hydroxybutyryl-CoA) can act as a cofactor for lysine β-hydroxybutyrylation (Kbhb), with elevated levels of histone Kbhb in a streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) mouse model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 103404-51-9
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Appearance Solid
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Molecular Weight 874.45
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Formula C25H42Li3N7O18P3S
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Color White to off-white
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSC(CC(C)O)=O)=O)=O)O)C)=O)=O)O3.[Li].[Li].[Li]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
H2O : 50 mg/mL (57.18 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Kevin B Koronowski, et al. Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation. Cell Rep. 2021 Aug 3;36(5):109487. [Content Brief]
[2]. Zhongyu Xie, et al. Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. Mol Cell. 2016 Apr 21;62(2):194-206. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.1436 mL | 5.7179 mL | 11.4358 mL | 28.5894 mL |
| 5 mM | 0.2287 mL | 1.1436 mL | 2.2872 mL | 5.7179 mL | |
| 10 mM | 0.1144 mL | 0.5718 mL | 1.1436 mL | 2.8589 mL | |
| 15 mM | 0.0762 mL | 0.3812 mL | 0.7624 mL | 1.9060 mL | |
| 20 mM | 0.0572 mL | 0.2859 mL | 0.5718 mL | 1.4295 mL | |
| 25 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1436 mL | |
| 30 mM | 0.0381 mL | 0.1906 mL | 0.3812 mL | 0.9530 mL | |
| 40 mM | 0.0286 mL | 0.1429 mL | 0.2859 mL | 0.7147 mL | |
| 50 mM | 0.0229 mL | 0.1144 mL | 0.2287 mL | 0.5718 mL |
DL-β-Hydroxybutyryl coenzyme A lithium Related Classifications
HY-134426 Related Classifications
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