2. PROTAC
  3. Ligands for E3 Ligase
  4. E3 ligase Ligand 82

E3 ligase Ligand 82 is an E3 ligase VHL ligand. E3 ligase Ligand 82 can be coupled with BRD4 ligand JQ-1 carboxylic acid (HY-78695) via the linker Hydroxy-PEG3-CH2-Boc (HY-141209) to form PROTAC BRD4 Degrader-23 (HY-161093).

For research use only. We do not sell to patients.

E3 ligase Ligand 82

E3 ligase Ligand 82 Chemical Structure

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E3 ligase Ligand 82 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41 RNF114 DDB1 FEM1B

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Description

E3 ligase Ligand 82 is an E3 ligase VHL ligand. E3 ligase Ligand 82 can be coupled with BRD4 ligand JQ-1 carboxylic acid (HY-78695) via the linker Hydroxy-PEG3-CH2-Boc (HY-141209) to form PROTAC BRD4 Degrader-23 (HY-161093)[1].

IC50 & Target

VHL

 

Molecular Weight

741.90

Formula

C40H47N5O7S
SMILES

CC(C)(C)[C@@H](CN1[C@H](C(N(CC2=CC=C(C3=C(C)N=CS3)C=C2)CC4=CC(C(C=CC=C5)=C5O6)=C6C=C4[N+]([O-])=O)=O)C[C@@H](O)C1)NC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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E3 ligase Ligand 82 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E3 ligase Ligand 82Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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E3 ligase Ligand 82
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HY-175797
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