PROTAC BRD4 Degrader-23

PROTAC BRD4 Degrader-23 is a visible light-regulated BRD4 PROTAC degrader, with DC₅₀ values of 6871 nM and < 30 nM in the dark and under light exposure, respectively; its IC₅₀ values are 1172 nM and 140 nM under the corresponding conditions. PROTAC BRD4 Degrader-23 shows inhibited activity in dark environments, and recovers BRD4 degradation ability upon irradiation with 405 nm visible light. PROTAC BRD4 Degrader-23 inhibits tumor cell proliferation in a visible light-dependent manner. PROTAC BRD4 Degrader-23 can be used in studies of BRD4-dependent B-cell lymphoma.
(Pink: BRD4 ligand (HY-78695); Blue: VHL ligand (HY-175797); Black: linker (HY-141209)).

• Data Sheet (268 KB)