2. Stem Cell/Wnt
  3. Wnt
  4. Fz7-21

Fz7-21  (Synonyms: Ac-LPSDDLEFWCHVMY-NH2)

製品番号: HY-P1454 純度: 99.31%
COA 取扱説明書 Technical Support

Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids.

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カスタムペプチド

CAS 番号 : 2247635-23-8

容量 価格（税別） 在庫状況 数量
1 mg $85 在庫あり
5 mg $220 在庫あり
10 mg $350 在庫あり
25 mg $595 在庫あり
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100 mg   お問い合わせ  

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カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of Fz7-21:

Fz7-21 関連抗体

Top Publications Citing Use of Products

    Fz7-21 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2023 Oct;56(10):e13460.  [Abstract]

    Fz7-21 (200 nM; 14 days) downregulates the expression of the stemness biomarker ΔNp63α in hLESCs.

    Fz7-21 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2023 Oct;56(10):e13460.  [Abstract]

    Fz7-21 (200 nM; 14 days) inhibits the release of Ca2+ induced by WNT16b in hLESCs.

    Fz7-21 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2023 Oct;56(10):e13460.  [Abstract]

    Fz7-21 (200 nM; 14 days) suppresses hLESC proliferation induced by WNT16b in hLESCs.

    Fz7-21 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2023 Oct;56(10):e13460.  [Abstract]

    Fz7-21 (200 nM; 14 days) decreases the expression of Calcineurin A and NFATC2 in hLESCs.

    Wnt アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

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    製品説明

    Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids[1][2].

    IC50 & Target

    EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)[1]
    体外実験

    Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (0-100μM; 6 h; HEK293-TB cells) impairs Wnt signaling with IC50 value of 100?nM[1].
    Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (1?μM) blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 value of 50?nM[1].
    Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (200 μM; 48 h; LGR5–GFP+ stem cells) disrupts LGR5+ stem cell function[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Fz7-21 関連抗体
    分子量

    1796.05

    分子式

    C83H114N18O23S2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    Sequence Shortening

    Ac-LPSDDLEFWCHVMY-NH2
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    polypeptide, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (55.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.5568 mL 2.7839 mL 5.5678 mL
    5 mM 0.1114 mL 0.5568 mL 1.1136 mL
    10 mM 0.0557 mL 0.2784 mL 0.5568 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    一般には略語で表示されます：C1V1 = C2V2

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    純度とドキュメンテーション

    純度: 99.31%

    COA (244 KB) LCMS (342 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.5568 mL 2.7839 mL 5.5678 mL 13.9194 mL
    5 mM 0.1114 mL 0.5568 mL 1.1136 mL 2.7839 mL
    10 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3919 mL
    15 mM 0.0371 mL 0.1856 mL 0.3712 mL 0.9280 mL
    20 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL
    25 mM 0.0223 mL 0.1114 mL 0.2227 mL 0.5568 mL
    30 mM 0.0186 mL 0.0928 mL 0.1856 mL 0.4640 mL
    40 mM 0.0139 mL 0.0696 mL 0.1392 mL 0.3480 mL
    50 mM 0.0111 mL 0.0557 mL 0.1114 mL 0.2784 mL
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    Fz7-21 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Fz7-212247635-23-8Ac-LPSDDLEFWCHVMY-NH2WntFZD7conformationlipid-binding grooveFZD7 CRDWnt-β-cateninintestinal organoidsInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-P1454
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