Antiproliferative agent-49
Antiproliferative agent-49 (Compound 5a) is a EGFR-TK inhibitor with an IC50 of 0.09 μM. Antiproliferative agent-49 is a anti-proliferative agent. Antiproliferative agent-49 displays good activities against HER3 and HER4 with IC50 values 0.18 and 0.37 µM. Antiproliferative agent-49 induces mitochondrial apoptotic pathway and increased accumulation of ROS.
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- Fòrmula: C22H18N2O2S
- Peso molecular:374.46
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
Antiproliferative agent-49 (0.09 μM, 24 h) arrests the HepG-2 cell cycle in the G1/S phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 374.46
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Fòrmula C22H18N2O2S
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SMILES
C1(SCC2=CC=CC=C2)=NN=C(C3=CC=C(OCC4=CC=CC=C4)C=C3)O1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiproliferative agent-49 Related Classifications
HY-158016 Related Classifications
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