CGP 20712
CGP 20712 is a highly selective β1-adrenoceptor antagonist (Ki=0.3 nmol/L). CGP 20712’s primary mechanism of action is through competitively binding to β1-receptors, thereby blocking the positive chronotropic effects of adrenaline and noradrenaline.
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- No. CAS: 137888-49-4
- Fòrmula: C23H25F3N4O5
- Peso molecular:494.46
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas Adrenergic Receptor
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | EC50 |
10 μM
Compound: CGP 20712A
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Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
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[PMID: 23614528] |
Chemical Information
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No. CAS 137888-49-4
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Peso molecular 494.46
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Fòrmula C23H25F3N4O5
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SMILES
O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGP 20712 Related Classifications
HY-101355 Related Classifications
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