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PMX 53 monoacetate

(Synonyms: 3D53 monoacetate)
9 Cited Publications
Revisión del cliente

Based on 9 publication(s) in Google Scholar

PMX 53 monoacetate (3D53 monoacetate) is a potent orally active CD88 (C5aR) antagonist that inhibits C5a-induced neutrophil myeloperoxide release and chemotactic activity. PMX 53 monoacetate has an IC50 value of 20 nM against C5a-induced neutrophil myeloperoxide release. >The value is 22 nM, and the IC50 value of the chemotactic activity is 75 nM. PMX 53 monoacetate is also an agonist of MrgX2.

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  • No. CAS: 852629-88-0
  • Fòrmula: C49H69N11O9
  • Peso molecular:956.14
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • PMX 53 monoacetate Chemical Structure
    PMX 53 monoacetate Chemical Structure
  • Experimental Validation Results for PMX 53 monoacetate
  • Experimental Validation Results for PMX 53 monoacetate
  • Experimental Validation Results for PMX 53 monoacetate
  • Experimental Validation Results for PMX 53 monoacetate
  • Experimental Validation Results for PMX 53 monoacetate
No. CAS: 852629-88-0
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  • PMX 53 monoacetate Chemical Structure
    PMX 53 monoacetate Chemical Structure
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    PMX 53 monoacetate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Aug 2;31(8):2507-2523. [Abstract]

    Customer Validation
     Chemotaxis of THP1 cells toward medium without FBS (control), medium without FBS + 0.1 μg/mL of C5a (C5a), and THP1 cells pre-treated 30 min with 0.9 μg/mL PMX53 toward medium without FBS + 0.1 μg/mL C5a (PMX53 + C5a) was evaluated. After 2 h of migration, RFU (Ex/Em = 485/520 nm) was measured.

  • 1/16

    PMX 53 monoacetate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Aug 2;31(8):2507-2523. [Abstract]

    Customer Validation
     Western blotting of phosphoS6, phosphoHSP27, phosphoERK, and the loading control β-actin of THP1 cells untreated or treated with PMX53 (0.9 μg/mL) and/or C5a for 30 min. The experiment was performed three times with similar results.

  • 1/16

    PMX 53 monoacetate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Aug 2;31(8):2507-2523. [Abstract]

    Customer Validation
     Chemotaxis of primary monocytes isolated from WT and C5aR1-/- mice toward medium without FBS, medium without FBS + 0.1 μg/mL of C5a (C5a). Migration of WT monocytes pre-treated for 30 min with 0.9 μg/mL PMX53 toward medium without FBS + 0.1 μg/mL C5a was also evaluated n = 4–6.

  • 1/16

    PMX 53 monoacetate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Aug 2;31(8):2507-2523. [Abstract]

    Customer Validation
     Schematic representation of the pharmacological inhibition of C5aR1 in the DoxoR-induced senescence model. At day 0, 15-week-old mice received either vehicle or DoxoR (10 mg/kg, i.p.). From day 1 to day 30, mice received PMX53 (1 mg/kg, daily subcutaneous) or vehicle 2.

  • 1/16

    PMX 53 monoacetate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Aug 2;31(8):2507-2523. [Abstract]

    Customer Validation
     Schematic representation of the pharmacological inhibition of C5aR1 in the DoxoR-induced senescence model. At day 0, 15-week-old mice received either vehicle or DoxoR (10 mg/kg, i.p.). From day 1 to day 30, mice received PMX53 (1 mg/kg, daily subcutaneous) or vehicle 2. Quantitative parameters and 3D representation of the cortical bone of tibiae measured by μ-CT.

  • PMX 53 monoacetate