Solabegron hydrochloride
Based on 1 publication(s) in Google Scholar
Solabegron hydrochloride is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM. Solabegron hydrochloride (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome.
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- No. CAS: 451470-34-1
- Fòrmula: C23H24Cl2N2O3
- Peso molecular:447.35
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Almacenamiento:
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 451470-34-1
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Peso molecular 447.35
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Fòrmula C23H24Cl2N2O3
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SMILES
O=C(C1=CC(C2=CC=CC(NCCNC[C@@H](C3=CC=CC(Cl)=C3)O)=C2)=CC=C1)O.[H]Cl
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Synonyms
GW 427353B
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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PLoS One
Vibegron shows high selectivity and potent agonist activity for β3-adrenoceptors, irrespective of receptor density. [Abstract]2023 Sep 1;18(9):e0290685. PMID: 37656760
Pureza y Documentación
Referencias
[1]. Hicks A, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323(1):202-9. [Content Brief]
[2]. Andersson KE, et al. Selective β3-adrenoceptor agonists for the treatment of overactive bladder. J Urol. 2013 Oct;190(4):1173-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Solabegron hydrochloride Related Classifications
HY-19436A Related Classifications
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