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Referencia número: HY-164988

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TX2-120-1

TX2-120-1 possesses the ability to bind to Her3, with an IC₅₀ value of 56 nM for Her3. TX2-120-1 can be used for the synthesis of TX2-121-1 (HY-118998).

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No. CAS: 1603845-45-9
Fòrmula: C₂₆H₂₇N₇O₂
Peso molecular:469.54

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

TX2-120-1 Chemical Structure

No. CAS: 1603845-45-9

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

TX2-120-1 possesses the ability to bind to Her3, with an IC₅₀ value of 56 nM for Her3. TX2-120-1 can be used for the synthesis of TX2-121-1 (HY-118998)^[1].

IC₅₀ & Target

HER3

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In Vivo

TX2-120-1 (0.5-2 μM; 12 h), due to the absence of the hydrophobic adamantane group, exhibits poorer efficacy in inducing Her3 degradation or blocking Her3-dependent signaling in PC9 GR4 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1603845-45-9
Peso molecular 469.54
Fòrmula C₂₆H₂₇N₇O₂
SMILES

CN1CCC(N2C3=NC=NC(N)=C3C(C(C=C4)=CC(NC(C=C)=O)=C4OC5=CC=CC=C5)=N2)CC1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Lim S M, et al. Development of small molecules targeting the pseudokinase Her3[J]. Bioorganic & medicinal chemistry letters, 2015, 25(16): 3382-3389. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

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TX2-120-1

Ver todos los productos específicos de isoformas EGFR