1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. Gefitinib N-oxide

Gefitinib N-oxide 

Cat. No.: HY-100636
Handling Instructions

Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells.

For research use only. We do not sell to patients.

Gefitinib N-oxide Chemical Structure

Gefitinib N-oxide Chemical Structure

CAS No. : 847949-51-3

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Description

Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].

IC50 & Target

IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)[1]

Molecular Weight

462.90

Formula

C₂₂H₂₄ClFN₄O₄

CAS No.

847949-51-3

SMILES

[O-][N+]1(CCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)CCOCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Gefitinib N-oxideEGFREpidermal growth factor receptorErbB-1HER1N-oxidederivativeGefitinibInhibitorinhibitorinhibit

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Gefitinib N-oxide
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