2. Gene
  3. Cx3cr1 - chemokine (C-X3-C motif) receptor 1 Gene

Cx3cr1 - chemokine (C-X3-C motif) receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mCX3CR1

Gene ID: 13051 | Gene type: protein coding

About Cx3cr1

Chromosome 9: 119,730,682-119,898,945 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 259 orthologues, 25 paralogues and is associated with 50 phenotypes. Ubiquitous expression in cortex adult (RPKM 8.3), frontal lobe adult (RPKM 7.) and 27 other tissues.

Summary

Enables C-X3-C chemokine binding activity and C-X3-C Chemokine Receptor activity. Involved in several processes, including leukocyte migration; nervous system development; and synapse organization. Acts upstream of or within several processes, including macrophage chemotaxis; microglial cell activation involved in immune response; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cell surface. Is expressed in several structures, including colon; genitourinary system; and liver. Used to study age related macular degeneration 12. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cx3cr1 Products(1)

mRNA Protein Name
NM_009987.4 NP_034117.3 CX3C chemokine receptor 1

Cx3cr1 Protein Structure

7tmA_CX3CR1

7tmA_CX3CR1: cd15186 (32 - 59)

7tmA_CX3CR1

7tmA_CX3CR1: cd15186 (32 - 304)

7tmA_CX3CR1

7tmA_CX3CR1: cd15186 (66 - 91)

7tmA_CX3CR1

7tmA_CX3CR1: cd15186 (102 - 132)

7tmA_CX3CR1

7tmA_CX3CR1: cd15186 (144 - 166)

7tmA_CX3CR1

7tmA_CX3CR1: cd15186 (188 - 216)

7tmA_CX3CR1

7tmA_CX3CR1: cd15186 (224 - 254)

7tmA_CX3CR1

7tmA_CX3CR1: cd15186 (272 - 297)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

CX3C chemokine receptor 1

C-X3-C CKR-1

chemokine (C-X3-C) receptor 1

fractalkine receptor

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-13848 AZD8797 98.73% Phase 2
HY-107456 E6130 ≥98.0% Phase 1
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123918 JMS-17-2 99.90% Unkown
HY-123918A JMS-17-2 hydrochloride / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cx3cr1 NCBI NCBI:1524