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Cx3cr1 - chemokine (C-X3-C motif) receptor 1 Gene

Also Known as mCX3CR1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13051

About Cx3cr1

Chromosome 9: 119,730,682-119,898,945 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 259 orthologues, 25 paralogues and is associated with 50 phenotypes. Ubiquitous expression in cortex adult (RPKM 8.3), frontal lobe adult (RPKM 7.) and 27 other tissues.

Summary

Enables C-X3-C chemokine binding activity and C-X3-C Chemokine Receptor activity. Involved in several processes, including leukocyte migration; nervous system development; and synapse organization. Acts upstream of or within several processes, including macrophage chemotaxis; microglial cell activation involved in immune response; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cell surface. Is expressed in several structures, including colon; genitourinary system; and liver. Used to study age related macular degeneration 12. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cx3cr1 Products (1)

mRNA	Protein	Name
NM_009987.4	NP_034117.3	CX3C chemokine receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C-X3-C chemokine binding	IPI IPI: Inferred from physical interaction	10187784	MGI
enables C-X3-C chemokine receptor activity	IDA IDA: Inferred from direct assay	10187784	MGI
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	10187784	MGI
enables cytokine receptor activity	IMP IMP: Inferred from mutant phenotype	18971423	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adaptive immune response	IMP IMP: Inferred from mutant phenotype	29326275	MGI
involved in antifungal innate immune response	IMP IMP: Inferred from mutant phenotype	29326275	MGI
involved in brain development	IMP IMP: Inferred from mutant phenotype	21778362	MGI
involved in cell adhesion	IPI IPI: Inferred from physical interaction	10187784	MGI
involved in cellular response to lipopolysaccharide	IGI IGI: Inferred from genetic interaction	23499256	MGI
involved in central nervous system maturation	IMP IMP: Inferred from mutant phenotype	24487234	MGI
involved in host-mediated regulation of intestinal microbiota composition	IMP IMP: Inferred from mutant phenotype	15653504	MGI
involved in immune response	IMP IMP: Inferred from mutant phenotype	15653504	MGI
involved in leukocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	16675847	MGI
involved in leukocyte tethering or rolling	IGI IGI: Inferred from genetic interaction	10187784	MGI
involved in microglial cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	16732273	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	24487234	MGI
involved in multiple spine synapse organization, single dendrite	IMP IMP: Inferred from mutant phenotype	24487234	MGI
involved in negative regulation of microglial cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	16732273	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10187784	MGI
involved in positive regulation of monocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	12871640	MGI
involved in positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	20018408	MGI
involved in regulation of nitric oxide biosynthetic process	IGI IGI: Inferred from genetic interaction	23499256	MGI
involved in regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	23499256	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	24487234	MGI
involved in synapse maturation	IMP IMP: Inferred from mutant phenotype	24487234	MGI
involved in synapse pruning	IMP IMP: Inferred from mutant phenotype	21778362	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	10187784	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cx3cr1 Protein Structure

7tmA_CX3CR1

0
100
200
300
354 a.a.

Protein Preferred Names	Protein Names
CX3C chemokine receptor 1	C-X3-C CKR-1 chemokine (C-X3-C) receptor 1 fractalkine receptor

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928	Alirocumab		97.00%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13848	Rugocrixan		99.54%	Phase 2
HY-107456	E6130		98.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123918	JMS-17-2		99.18%	Unkown
HY-175746	AZD0233	Antagonist	98.66%	Unkown
HY-123918A	JMS-17-2 hydrochloride		/	Unkown
HY-168975	Fosrugocrixan	Antagonist	/	Unkown
HY-179653	CX3CR1-IN-1	Inhibitor	/	Unkown
HY-181016	CX3CR1-IN-2	Inhibitor	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928A	Alirocumab (anti-PCSK9)		98.24%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cx3cr1	NCBI	NCBI:1524