Gli3 - GLI family zinc finger 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140588

Summary

Predicted to enable several functions, including beta-catenin binding activity; enzyme binding activity; and mediator complex binding activity. Involved in gland development; response to estrogen; and wound healing. Located in cytoplasm and nucleus. Biomarker of clubfoot; hypospadias; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (Gli family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Gli3 Products (1)

mRNA Protein Name
NM_080405.2 NP_536330.2 transcriptional activator GLI3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in liver regeneration IEP
IEP: Inferred from expression pattern
22024090 RGD
involved in prostate gland development IEP
IEP: Inferred from expression pattern
15328011 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
15328011 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional activator GLI3

  • GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05476 GLI3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05482 GLIS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118032 Bozepinib / Unkown
HY-RS21349 Gli3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27868 Gli3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29495 Glis3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gli3 NCBI NCBI:2737