ARL6IP6 - ADP ribosylation factor like GTPase 6 interacting protein 6 Gene

Also Known as AIP6; AIP-6; PFAAP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 151188

About ARL6IP6

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:152,717,648-152,762,396 (from NCBI)

This gene has 23 transcripts (splice variants), 176 orthologues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 7.1), bone marrow (RPKM 6.2) and 25 other tissues.

Summary

Predicted to be located in nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARL6IP6 Products (3)

mRNA Protein Name
NM_001350068.2 NP_001336997.1 ADP-ribosylation factor-like protein 6-interacting protein 6 isoform b
NM_001371972.1 NP_001358901.1 ADP-ribosylation factor-like protein 6-interacting protein 6 isoform c
NM_152522.7 NP_689735.1 ADP-ribosylation factor-like protein 6-interacting protein 6 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 6-interacting protein 6

  • ADP-ribosylation factor GTPase 6 interacting protein 6

ARL6IP6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARL6IP6 Q8N6S5 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
ARL6IP6 Q8N6S5 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 GPR61 Homo sapiens Q9BZJ8
Validated Y2H
32296183
Intra
ARL6IP6 Q8N6S5 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 TBXA2R Homo sapiens Q0VAB0
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 TBXA2R Homo sapiens Q0VAB0
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 CMTM2 Homo sapiens Q8TAZ6
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 CMTM2 Homo sapiens Q8TAZ6
Validated Y2H
32296183
Intra
ARL6IP6 Q8N6S5 CMTM2 Homo sapiens Q8TAZ6
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
ARL6IP6 Q8N6S5 TMEM205 Homo sapiens Q6UW68
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 TMEM205 Homo sapiens Q6UW68
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 RUSF1 Homo sapiens Q96GQ5
Y2H Prey Pooling
32296183
Intra
ARL6IP6 Q8N6S5 RUSF1 Homo sapiens Q96GQ5
Y2H Array
32296183
Intra
ARL6IP6 Q8N6S5 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ARL6IP6 Proteins

Cat. No. Product Name Accession Purity
HY-P76730 ARL6IP6 Protein, Human (HEK293, Fc) Q8N6S5/NP_689735.1 (M1-S110) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cutis Marmorata Telangiectatica Congenita

  • CMTC

  • Hereditary Cutis Marmorata Telangiectatica Congenita

  • Van Lohuizen Syndrome
Mongolian Spot

  • Mongolian Macula
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00997 ARL6IP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18720 Arl6ip6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25207 Arl6ip6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARL6IP6 VGNC VGNC:38121
Rattus norvegicus ARL6IP6 RGD RGD:1564819
Felis catus ARL6IP6 VGNC VGNC:107488
Macaca mulatta ARL6IP6 VGNC VGNC:104510
Mus musculus ARL6IP6 MGD MGI:1929507
Bos taurus ARL6IP6 VGNC VGNC:26152
Others ARL6IP6 NCBI