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LINGO2 - leucine rich repeat and Ig domain containing 2 Gene

Also Known as LERN3; LRRN6C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 158038

About LINGO2

Cytogenetic location: 9p21.2-p21.1 Genomic coordinates (GRCh38): 9:27,937,617-29,213,601 (from NCBI)

This gene has 9 transcripts (splice variants), 274 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LINGO2 Products (4)

mRNA	Protein	Name
NM_001258282.3	NP_001245211.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor
NM_001354574.2	NP_001341503.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor
NM_001354575.2	NP_001341504.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor
NM_152570.4	NP_689783.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor

LINGO2 Protein Structure

LRRNT

LRR_8

LRR_1

LRR_8

I-set

0
100
200
300
400
500
606 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2	leucine rich repeat neuronal 6C

Related Diseases

Diseases	Alias
Essential Tremor	Benign Essential Tremor Familial Tremor Hereditary Essential Tremor Essential Hereditary Tremor Shaky Hand Syndrome Benign Essential Tremor Syndrome Tremor Hereditary Essential Essential Tremor, Susceptibility To Tremor, Hereditary Essential
Tremor, Hereditary Essential, 5	ETM5 Essential Tremor 5 Essential Tremor, Hereditary, 5 Hereditary Essential Tremor 5 Tremor, Hereditary Essential 5 Tremor, Essential Hereditary, Type 5
Tremor, Hereditary Essential, 4	ETM4 Essential Tremor 4 Essential Tremor, Hereditary, 4 Hereditary Essential Tremor 4 Tremor, Hereditary Essential 4 Tremor, Hereditary Essential, Type 4
Tremor, Hereditary Essential, 1	ETM1 Fet1 Essential Tremor 1 Tremor, Familial Essential, 1 Essential Tremor, Hereditary, 1 Hereditary Essential Tremor 1 Tremor Hereditary Essential, 1 Tremor Familial Essential, 1 Tremor, Hereditary Essential 1 Tremor, Essential Hereditary, Type 1
Ectodermal Dysplasia 14, Hair/Tooth Type With Or Without Hypohidrosis	ECTD14 Ectodermal Dysplasia 14 Ectn14
Motion Sickness	Airsickness Carsickness Seasickness Travel Sickness Riders' Vertigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07681	LINGO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21146	Lingo2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27663	Lingo2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LINGO2	VGNC	VGNC:63237
Canis familiaris	LINGO2	VGNC	VGNC:42689
Rattus norvegicus	LINGO2	RGD	RGD:1310773
Bos taurus	LINGO2	VGNC	VGNC:30900
Mus musculus	LINGO2	MGD	MGI:2442298
Macaca mulatta	LINGO2	VGNC	VGNC:74095
Others	LINGO2	NCBI