Pikfyve - phosphoinositide kinase, FYVE type zinc finger containing Gene

Also Known as p235; Pip5k; Pip5k3; Pipk5k3; PipkIII; 5230400C17Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18711

About Pikfyve

Chromosome 1: 65,225,842-65,317,854 forward strand.GRCm39:CM000994.3

This gene has 11 transcripts (splice variants), 205 orthologues, 13 paralogues and is associated with 46 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 3.4), CNS E18 (RPKM 3.3) and 28 other tissues.

Summary

Enables phosphotransferase activity, alcohol group as acceptor and zinc ion binding activity. Involved in several processes, including neutrophil chemotaxis; phosphatidylinositol metabolic process; and vesicle organization. Acts upstream of or within myelin assembly. Located in several cellular components, including cell-cell junction; perinuclear region of cytoplasm; and vesicle membrane. Is expressed in brain; genitourinary system; integumental system; limb; and skeleton. Used to study Crohn's disease. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKfyve (phosphoinositide kinase, FYVE-type zinc finger containing). [provided by Alliance of Genome Resources, Apr 2022]

Pikfyve Products (2)

mRNA	Protein	Name
NM_001310624.1	NP_001297553.1	1-phosphatidylinositol 3-phosphate 5-kinase isoform 1
NM_011086.2	NP_035216.2	1-phosphatidylinositol 3-phosphate 5-kinase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity	IDA IDA: Inferred from direct assay	10419465	MGI
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA IDA: Inferred from direct assay	9858586	MGI
enables 1-phosphatidylinositol-5-kinase activity	IDA IDA: Inferred from direct assay	10419465	MGI
enables kinase activity	IDA IDA: Inferred from direct assay	14530284	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14530284	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11123925	MGI
enables zinc ion binding	IDA IDA: Inferred from direct assay	9858586	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process	IDA IDA: Inferred from direct assay	11123925	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	9858586	MGI
involved in melanosome organization	IMP IMP: Inferred from mutant phenotype	29584722	MGI
acts upstream of or within myelin assembly	IGI IGI: Inferred from genetic interaction	22028665	MGI
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	28779020	MGI
NOT involved in neutrophil degranulation	IDA IDA: Inferred from direct assay	28779020	MGI
involved in peptidyl-serine autophosphorylation	IDA IDA: Inferred from direct assay	11123925	MGI
involved in phagosome maturation	IDA IDA: Inferred from direct assay	27623384	MGI
involved in phagosome-lysosome fusion	IDA IDA: Inferred from direct assay	28779020	MGI
involved in phosphatidylinositol 5-phosphate metabolic process	IDA IDA: Inferred from direct assay	11123925	MGI
involved in protein targeting to membrane	IDA IDA: Inferred from direct assay	14530284	MGI
involved in regulation of reactive oxygen species biosynthetic process	IDA IDA: Inferred from direct assay	28779020	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	11112776	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11112776	MGI
NOT located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	11112776	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19056739	MGI
located in vesicle membrane	IDA IDA: Inferred from direct assay	9858586	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pikfyve Protein Structure

FYVE_PIKfyve_Fab1

DEP_PIKfyve

Fab1_TCP

PIPKc_PIKfyve

0
400
800
1200
1600
2000
2097 a.a.

Protein Preferred Names	Protein Names
1-phosphatidylinositol 3-phosphate 5-kinase	FYVE finger-containing phosphoinositide kinase PIPkin-III PtdIns(4)P-5-kinase phosphatidylinositol 3-phosphate 5-kinase type III phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III phosphatidylinositol-4-phosphate 5-kinase, type III phosphoinositide kinase, FYVE finger containing serine-protein kinase PIKFYVE type III PIP kinase

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14644	Apilimod	Inhibitor	99.80%	Phase 2

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-118630	Vacuolin-1	Inhibitor	98.54%	Unkown
HY-13228	YM-201636	Inhibitor	98.07%	Unkown
HY-14644A	Apilimod mesylate	Inhibitor	99.58%	Unkown
HY-15982	APY0201	Inhibitor	99.42%	Unkown
HY-119624	MOMIPP	Inhibitor	99.00%	Unkown
HY-155994	PIK5-12d	Degrader	99.15%	Unkown
HY-151473	PIKfyve-IN-1	Inhibitor	99.64%	Unkown
HY-160477	DC-SX029	Inhibitor	98.07%	Unkown
HY-153119	TMX-4153	Degrader	98.96%	Unkown
HY-161619	RMC-113	Inhibitor	99.54%	Unkown
HY-159625	WX8	Inhibitor	99.43%	Unkown
HY-154956	PIKfyve-IN-2	Inhibitor	98.0%	Unkown
HY-163943	UNI418	Inhibitor	99.61%	Unkown
HY-163133	PIKfyve-IN-3		99.55%	Unkown
HY-170909	PIKfyve-IN-4	Inhibitor	99.53%	Unkown
HY-123876	AS2677131	Inhibitor	/	Unkown
HY-177432	TMX-4140	Inhibitor	/	Unkown
HY-177091	AS2795440	Inhibitor	/	Unkown
HY-175631	PIKfyve ligand-1	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pikfyve	NCBI	NCBI:200576