FGF5 - fibroblast growth factor 5 Gene

Also Known as HBGF-5; TCMGLY; Smag-82

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2250

About FGF5

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:80,266,588-80,291,017 (from NCBI)

This gene has 5 transcripts (splice variants), 199 orthologues, 21 paralogues and is associated with 2 phenotypes. Biased expression in gall bladder (RPKM 2.1), kidney (RPKM 0.5) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

FGF5 Products (3)

mRNA	Protein	Name
NM_001291812.2	NP_001278741.1	fibroblast growth factor 5 isoform 3
NM_004464.4	NP_004455.2	fibroblast growth factor 5 isoform 1 precursor
NM_033143.2	NP_149134.1	fibroblast growth factor 5 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables fibroblast growth factor receptor binding	IDA IDA: Inferred from direct assay	8386828	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	8386828	GOA
acts upstream of or within fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	8663044	GOA
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	3211147	GOA
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	8663044	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGF5 Protein Structure

FGF

0
100
200
268 a.a.

Protein Preferred Names	Protein Names
fibroblast growth factor 5	heparin-binding growth factor 5

Recombinant FGF5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700067AF	Animal-Free FGF-5 Protein, Human (His)	AAB06463.1 (A18-G268)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Trichomegaly	Long Eyelashes TCMGLY Goldstein Hutt Syndrome Eyelashes, Long Movie Lashes
Familial Isolated Trichomegaly	Long Eyelashes Tcmgly
Hereditary Spherocytosis	Congenital Spherocytic Hemolytic Anemia Spherocytic Anemia Congenital Spherocytosis Spherocytosis, Type 1 Minkowski Chauffard Syndrome Hs Minkowski-Chauffard Disease Minkowski-Chauffard Syndrome Spherocytosis Hereditary Spherocytosis, Hereditary Anemia, Hereditary Spherocytic Hemolytic
Hypertrichosis
Androgenic Alopecia	Androgenetic Alopecia Alopecia Androgenetica, Male Pattern Baldness
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Telogen Effluvium
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04903	FGF5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174695	Human FGF5 mRNA		/	Unkown
HY-RS17054	Fgf5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23498	Fgf5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FGF5	MGD	MGI:95519
Rattus norvegicus	FGF5	RGD	RGD:620129
Bos taurus	FGF5	VGNC	VGNC:28980
Felis catus	FGF5	VGNC	VGNC:62253
Canis familiaris	FGF5	VGNC	VGNC:40851
Macaca mulatta	FGF5	VGNC	VGNC:82145
Others	FGF5	NCBI