P2RX2 - purinergic receptor P2X 2 Gene

Homo sapiens

Also known as P2X2; DFNA41

Gene ID: 22953 | Gene type: protein coding

About P2RX2

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:132,618,776-132,622,388 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 2 phenotypes.

Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]

P2RX2 Products(13)

mRNA	Protein	Name
NM_012226.5	NP_036358.2	P2X purinoceptor 2 isoform I
NM_174873.3	NP_777362.1	P2X purinoceptor 2 isoform B
NM_170682.4	NP_733782.1	P2X purinoceptor 2 isoform A
XM_005266156.6	XP_005266213.1	P2X purinoceptor 2 isoform X5
NM_174872.3	NP_777361.1	P2X purinoceptor 2 isoform H
XM_005266154.5	XP_005266211.1	P2X purinoceptor 2 isoform X1
XM_017019035.3	XP_016874524.1	P2X purinoceptor 2 isoform X4
NM_170683.4	NP_733783.1	P2X purinoceptor 2 isoform D
NM_001282164.2	NP_001269093.1	P2X purinoceptor 2 isoform J
NM_001282165.2	NP_001269094.1	P2X purinoceptor 2 isoform K
XM_005266155.6	XP_005266212.1	P2X purinoceptor 2 isoform X2
NM_016318.4	NP_057402.1	P2X purinoceptor 2 isoform C
XM_011534786.4	XP_011533088.1	P2X purinoceptor 2 isoform X3

P2RX2 Protein Structure

P2X_receptor

0
100
200
300
400
471 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 2

ATP receptor	P2X Receptor, subunit 2
purinergic receptor P2X, ligand gated ion channel, 2

Related Diseases

Diseases

Alias

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Deafness Type Dfna	Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Isolated Sensorineural Deafness Type Dfna	Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna	Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna

Low Compliance Bladder

Overactive Bladder	Hyperactivity Of Bladder
Hypertonic Bladder	Hypertonicity Of Bladder
Low Bladder Compliance	Oab - [Overactive Bladder]

Autosomal Dominant Nonsyndromic Deafness

Autosomal Dominant Deafness

Interstitial Cystitis

Bladder Pain Syndrome	Painful Bladder Syndrome
Ulcerative Cystitis	Ic/Bps
Ic/Pbs	Interstitial Cystitis/Bladder Pain Syndrome
Interstitial Cystitis/Painful Bladder Syndrome	Cystitis, Interstitial
Chronic Interstitial Cystitis	Pelvic Congestion Syndrome
Trigonitis

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Hearing Loss Disorder
Hearing Loss, Sensorineural	Central Hearing Loss
High Frequency Deafness	High Frequency Hearing Loss
High-Frequency Hearing Loss	Perceptive Deafness
Perceptive Hearing Loss	Perceptive Hearing Loss Or Deafness
Sensorineural Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Deafness, Autosomal Dominant 41

DFNA41	Autosomal Dominant Nonsyndromic Deafness 41
Autosomal Dominant Deafness 41	Deafness, Autosomal Dominant, 41
Deafness, Autosomal Dominant, Type 41

Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder	Neurogenic Urinary Bladder Disorder
Neuropathic Bladder	Bladder Neurogenic
Urinary Bladder, Neurogenic	Neurogenic Urinary Bladder

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Detrusor Sphincter Dyssynergia

Detrusor And Sphincter Dyssynergia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS09900	P2RX2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS09901	P2rx2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS09902	P2rx2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	P2RX2	MGD	MGI:2665170
Rattus norvegicus	P2RX2	RGD	RGD:620251
Macaca mulatta	P2RX2	VGNC	VGNC:75609
Bos taurus	P2RX2	VGNC	VGNC:32518
Felis catus	P2RX2	VGNC	VGNC:64009
Canis familiaris	P2RX2	VGNC	VGNC:44208

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