Alkbh5 - alkB homolog 5, RNA demethylase Gene

Also Known as Abh5; Ofoxd; E130207K11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 268420

Summary

Enables mRNA N6-methyladenosine dioxygenase activity. Involved in oxidative single-stranded RNA demethylation; regulation of mRNA stability; and spermatogenesis. Located in nuclear speck. Is expressed in brain. Orthologous to human ALKBH5 (alkB homolog 5, RNA demethylase). [provided by Alliance of Genome Resources, Apr 2022]

Alkbh5 Products (1)

mRNA Protein Name
NM_172943.4 NP_766531.2 RNA demethylase ALKBH5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables lysophospholipase activity IDA
IDA: Inferred from direct assay
16818490 MGI
enables mRNA N6-methyladenosine dioxygenase activity IMP
IMP: Inferred from mutant phenotype
29279410 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of gamma-delta T cell proliferation IMP
IMP: Inferred from mutant phenotype
35939687 MGI
involved in mRNA destabilization IMP
IMP: Inferred from mutant phenotype
36859428 MGI
involved in regulation of mRNA stability IMP
IMP: Inferred from mutant phenotype
29279410 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
23177736 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IMP
IMP: Inferred from mutant phenotype
29279410 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RNA demethylase ALKBH5

  • alkB, alkylation repair homolog 5

  • alkylated DNA repair protein alkB homolog 5

  • alpha-ketoglutarate-dependent dioxygenase alkB homolog 5

  • oxoglutarate and iron-dependent oxygenase domain containing

  • probable alpha-ketoglutarate-dependent dioxygenase ABH5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12304 IOX1 Inhibitor 99.89% Unkown
HY-155489 DDO-2728 98.64% Unkown
HY-165422 ALKBH5-IN-3 Inhibitor 99.63% Unkown
HY-172158 ALKBH5-IN-5 99.66% Unkown
HY-173020 W23-1006 97.15% Unkown
HY-W173146 ALKBH5-IN-4 98.82% Unkown
HY-149145 Ena15 ≥99.0% Unkown
HY-174979 Dac590 96.15% Unkown
HY-148933 ALKBH5-IN-2 Inhibitor / Unkown
HY-RS00606 ALKBH5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170668 DDO-02267 Inhibitor / Unkown
HY-179266 FTO-IN-15 Inhibitor / Unkown
HY-183325 FTO-IN-17 Inhibitor / Unkown
HY-N4031 Humantenine Chemical 98% Unkown
HY-RS16695 Alkbh5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23130 Alkbh5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alkbh5 NCBI NCBI:54890