GHSR - growth hormone secretagogue receptor Gene

Homo sapiens

Also known as GHDP

Gene ID: 2693 | Gene type: protein coding

About GHSR

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:172,443,291-172,448,456 (from NCBI)

This gene has 2 transcripts (splice variants), 218 orthologues, 15 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]

GHSR Products(2)

mRNA	Protein	Name
NM_198407.2	NP_940799.1	growth hormone secretagogue receptor type 1 isoform 1a
NM_004122.2	NP_004113.1	growth hormone secretagogue receptor type 1 isoform 1b

GHSR Protein Structure

7tm_1

0
100
200
300
366 a.a.

Protein Preferred Names

Protein Names

growth hormone secretagogue receptor type 1

GH-releasing peptide receptor	GHRP
GHS-R	ghrelin receptor

Related Diseases

Diseases

Alias

Pylorospasm

Froelich Syndrome

Froehlich'S Syndrome	Froelich'S Syndrome
Adiposogenital Syndrome	Babinski-Froelich Syndrome
Froehlich Syndrome

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15	Prader Willi Syndrome
Prader-Willi Syndrome Due To Imprinting Mutation	Upd(15)Mat

Growth Hormone Secreting Pituitary Adenoma

Somatotroph Adenoma	Growth Hormone-Secreting Pituitary Adenoma
Growth Hormone Producing Adenoma Of The Pituitary	Growth Hormone Secreting Adenoma Of Pituitary

Gastroparesis

Gastroparesis Syndrome	Delayed Gastric Emptying
Gastric Atonia	Gastroparalysis

Ileus

Ileus Of Intestine

Growth Hormone Deficiency, Isolated Partial

Short Stature Due To Growth Hormone Secretagogue Receptor Deficiency	GHDP
Short Stature Due To Ghsr Deficiency	Ghrelin Receptor Deficiency
Hormone, Growth, Deficiency, Isolated Partial	Short Stature, Idiopathic, Autosomal

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Alzheimer Disease 9

AD9	Alzheimer'S Disease 9
Alzheimer Disease 9, Susceptibility To	Alzheimer Disease 9, Late-Onset
Alzheimer'S Disease 9, Late Onset	{Alzheimer Disease 9, Susceptibility To}

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma	Prolactin-Secreting Pituitary Adenoma
Forbes-Albright Syndrome	Lactotroph Adenoma
Prl-Secreting Pituitary Adenoma	Prloma
Pituitary Lactotrophic Adenoma	Familial Prolactinoma
Pituitary Adenoma, Prolactin-Secreting	Prolactinoma Of Pituitary Gland
PSPA

Pituitary Adenoma

Pituitary Neoplasms	Adenoma Of The Pituitary Gland
Pituitary Adenomas	Adenoma, Pituitary
Pituitary Gland Adenoma

Diabetes Mellitus

Diabetes

Bulimia Nervosa

Bulimia	Bulimia Nervosa, Susceptibility To
Binge Eating Disorder	BULN
Bn	Hyperorexia Nervosa
Bulimia Nervosa 2	BULN2
Susceptibility To Bulimia Nervosa	Bulimia Nervosa, Susceptibility To, Type 2
Bn - [Bulimia Nervosa]	Bulimia Nos
Bulimic	Bingeing
Binge Overeating	Bouts Of Overeating
Episodes Of Overeating

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To	ANON
Anorexia Nervosa, Susceptibility To, 1	An
Anorexia Nervosa 1	An - [Anorexia Nervosa]

Acromegaly

Gigantism	Growth Hormone Excess
Pituitary Giant	Somatotroph Adenoma
Growth Hormone-Secreting Pituitary Adenoma

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Morbid Obesity Due To Leptin Deficiency	Obesity Morbid
Leptin Dysfunction	Leptin

Functional Gastric Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14734	Anamorelin	Agonist	99.64%	Unkown
HY-14734A	Anamorelin hydrochloride	Agonist	99.97%	Unkown
HY-14820A	Macimorelin acetate	Agonist	98.96%	Unkown
HY-14820	Macimorelin	Agonist	/	Unkown
HY-14734B	Anamorelin Fumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19884B	Relamorelin TFA	Agonist	99.89%	Phase 3
HY-19884A	Relamorelin acetate	Agonist	/	Phase 3
HY-14903	Ulimorelin	Agonist	/	Phase 3
HY-50844	Ibutamoren Mesylate	Agonist	99.86%	Phase 2
HY-P0231	AZP-531		98.54%	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103007	TC-G-1008	Agonist	99.61%	Unkown
HY-12584	PF-5190457	Inhibitor	98.34%	Unkown
HY-108699	TM-N1324	Agonist	99.91%	Unkown
HY-U00433	JMV 2959	Antagonist	99.91%	Unkown
HY-U00433A	JMV 2959 hydrochloride	Antagonist	98.09%	Unkown
HY-13964A	YIL781 hydrochloride	Antagonist	99.65%	Unkown
HY-P1366	des-Gln14-Ghrelin		98.61%	Unkown
HY-15243	Capromorelin Tartrate	Agonist	98.71%	Unkown
HY-10957	L-692429	Agonist	99.90%	Unkown
HY-P0089A	Human growth hormone-releasing factor TFA		96.02%	Unkown
HY-50760	L-692585	Agonist	99.32%	Unkown
HY-P0089	Human growth hormone-releasing factor		/	Unkown
HY-145364	Ghrelin receptor full agonist-2	Agonist	/	Unkown
HY-115272	GSK894490A	Agonist	/	Unkown
HY-116625	PF-04628935	Antagonist	/	Unkown
HY-113906	GSK1614343	Antagonist	/	Unkown
HY-P3594	[His1,Nle27] GHRF (1-32), amide, human		/	Unkown
HY-14495A	BMS-604992 free base	Agonist	/	Unkown
HY-153095	PF-6870961	Agonist	/	Unkown
HY-P1306	Obestatin(rat)		98.73%	Unkown
HY-137061	AZ-GHS-22	Antagonist	/	Unkown
HY-P3595	GHRF, porcine		/	Unkown
HY-14495	BMS-604992	Agonist	/	Unkown
HY-157556	BPP-2		/	Unkown
HY-P1366A	des-Gln14-Ghrelin TFA		/	Unkown
HY-P1432A	K-(D-1-Nal)-FwLL-NH2 TFA	Antagonist	/	Unkown
HY-153095A	PF-6870961 hydrochloride	Agonist	/	Unkown
HY-P3607	GHRF, bovine	Activator	/	Unkown
HY-P1432	K-(D-1-Nal)-FwLL-NH2	Antagonist	/	Unkown
HY-P1306A	Obestatin(rat) TFA		/	Unkown
HY-13964	YIL781	Antagonist	99.68%	Unkown
HY-14495B	BMS-604992 dihydrochloride	Agonist	/	Unkown
HY-15242	Capromorelin	Activator	/	Unkown
HY-113906A	(αR,8aS)-GSK1614343	Antagonist	99.40%	Unkown
HY-111232	GSK894281	Agonist	/	Unkown
HY-N12348	Emoghrelin	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GHSR	RGD	RGD:621397
Felis catus	GHSR	VGNC	VGNC:62548
Canis familiaris	GHSR	VGNC	VGNC:41210
Bos taurus	GHSR	VGNC	VGNC:29352
Mus musculus	GHSR	MGD	MGI:2441906
Macaca mulatta	GHSR	VGNC	VGNC:73051

Name
Email *

	Sorry, but the email address you supplied was invalid.