GHSR - growth hormone secretagogue receptor Gene

Also Known as GHDP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2693

About GHSR

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:172,443,291-172,448,456 (from NCBI)

This gene has 2 transcripts (splice variants), 218 orthologues, 15 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]

GHSR Products (2)

mRNA Protein Name
NM_198407.2 NP_940799.1 growth hormone secretagogue receptor type 1 isoform 1a
NM_004122.2 NP_004113.1 growth hormone secretagogue receptor type 1 isoform 1b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
8688086 GOA
enables growth hormone secretagogue receptor activity IDA
IDA: Inferred from direct assay
8688086 GOA
enables growth hormone-releasing hormone receptor activity IDA
IDA: Inferred from direct assay
8688086 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
27129257 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
27129257 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
8688086 GOA
involved in actin polymerization or depolymerization IDA
IDA: Inferred from direct assay
15232612 GOA
involved in decidualization IDA
IDA: Inferred from direct assay
17494105 GOA
involved in hormone-mediated signaling pathway IDA
IDA: Inferred from direct assay
8688086 GOA
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
15232612 GOA
involved in negative regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
15232612 GOA
involved in negative regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
15232612 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
15232612 GOA
involved in positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
16511605 GOA
involved in response to hormone IDA
IDA: Inferred from direct assay
15232612 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
8688086 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
15232612 GOA
located in neuron projection IDA
IDA: Inferred from direct assay
12890514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GHSR Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (60 - 323)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
Protein Preferred Names Protein Names

growth hormone secretagogue receptor type 1

  • GH-releasing peptide receptor

  • GHRP

  • GHS-R

  • ghrelin receptor

Related Diseases

Diseases Alias
Pylorospasm
Froelich Syndrome

  • Froehlich'S Syndrome

  • Froelich'S Syndrome

  • Adiposogenital Syndrome

  • Babinski-Froelich Syndrome

  • Froehlich Syndrome
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Upd(15)Mat
Growth Hormone Secreting Pituitary Adenoma

  • Somatotroph Adenoma

  • Growth Hormone-Secreting Pituitary Adenoma

  • Growth Hormone Producing Adenoma Of The Pituitary

  • Growth Hormone Secreting Adenoma Of Pituitary
Gastroparesis

  • Gastroparesis Syndrome

  • Delayed Gastric Emptying

  • Gastric Atonia

  • Gastroparalysis
Ileus

  • Ileus Of Intestine
Growth Hormone Deficiency, Isolated Partial

  • Short Stature Due To Growth Hormone Secretagogue Receptor Deficiency

  • GHDP

  • Short Stature Due To Ghsr Deficiency

  • Ghrelin Receptor Deficiency

  • Hormone, Growth, Deficiency, Isolated Partial

  • Short Stature, Idiopathic, Autosomal
Eating Disorder

  • Eating Disorders

  • Feeding And Eating Disorders
Alzheimer Disease 9

  • AD9

  • Alzheimer'S Disease 9

  • Alzheimer Disease 9, Susceptibility To

  • Alzheimer Disease 9, Late-Onset

  • Alzheimer'S Disease 9, Late Onset

  • {Alzheimer Disease 9, Susceptibility To}
Prolactinoma

  • Prolactin-Producing Pituitary Gland Adenoma

  • Prolactin-Secreting Pituitary Adenoma

  • Forbes-Albright Syndrome

  • Lactotroph Adenoma

  • Prl-Secreting Pituitary Adenoma

  • Prloma

  • Pituitary Lactotrophic Adenoma

  • Familial Prolactinoma

  • Pituitary Adenoma, Prolactin-Secreting

  • Prolactinoma Of Pituitary Gland

  • PSPA
Pituitary Adenoma

  • Pituitary Neoplasms

  • Adenoma Of The Pituitary Gland

  • Pituitary Adenomas

  • Adenoma, Pituitary

  • Pituitary Gland Adenoma
Diabetes Mellitus

  • Diabetes
Bulimia Nervosa

  • Bulimia

  • Bulimia Nervosa, Susceptibility To

  • Binge Eating Disorder

  • BULN

  • Bn

  • Hyperorexia Nervosa

  • Bulimia Nervosa 2

  • BULN2

  • Susceptibility To Bulimia Nervosa

  • Bulimia Nervosa, Susceptibility To, Type 2

  • Bn - [Bulimia Nervosa]

  • Bulimia Nos

  • Bulimic

  • Bingeing

  • Binge Overeating

  • Bouts Of Overeating

  • Episodes Of Overeating
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Anorexia Nervosa

  • Anorexia Nervosa, Susceptibility To

  • ANON

  • Anorexia Nervosa, Susceptibility To, 1

  • An

  • Anorexia Nervosa 1

  • An - [Anorexia Nervosa]
Acromegaly

  • Gigantism

  • Growth Hormone Excess

  • Pituitary Giant

  • Somatotroph Adenoma

  • Growth Hormone-Secreting Pituitary Adenoma
Leptin Deficiency Or Dysfunction

  • Morbid Obesity

  • Obesity Due To Congenital Leptin Deficiency

  • LEPD

  • Congenital Leptin Deficiency

  • Obesity, Morbid

  • Obesity, Morbid, Due To Leptin Deficiency

  • Severe Obesity

  • Obesity, Morbid, Nonsyndromic 1

  • Leptin Deficiency

  • Obesity, Severe, Due To Leptin Deficiency

  • Morbid Obesity Due To Leptin Deficiency

  • Obesity Morbid

  • Leptin Dysfunction

  • Leptin
Functional Gastric Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14734 Anamorelin Agonist 99.94% Unkown
HY-14734A Anamorelin hydrochloride Agonist 99.59% Unkown
HY-14820A Macimorelin acetate Agonist 99.34% Yes
HY-14820 Macimorelin Agonist / Unkown
HY-14734B Anamorelin Fumarate Agonist / Unkown

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-14903 Ulimorelin Agonist 96.10% Phase 3
HY-19884 Relamorelin Agonist / Phase 3
HY-P5645 LEAP-2 Antagonist 98.55% Phase 2
HY-12584 PF-5190457 Inhibitor 99.26% Phase 2
HY-10199A Ibutamoren Agonist 99.84% Phase 2
HY-15243 Capromorelin Tartrate Agonist 98.10% Phase 2
HY-15242 Capromorelin Activator / Phase 2
HY-P0231 AZP-531 99.36% Phase 1
HY-10957 L-692429 Agonist 99.53% Phase 1

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50844 Ibutamoren Mesylate Agonist 99.86% Unkown
HY-U00433 JMV 2959 Antagonist 99.91% Unkown
HY-13964A YIL781 hydrochloride Antagonist 99.48% Unkown
HY-19884B Relamorelin TFA Agonist 99.16% Unkown
HY-P1366 des-​Gln14-​Ghrelin 98.21% Unkown
HY-P10283 S1H Antagonist 99.32% Unkown
HY-13964 YIL781 Antagonist 99.68% Unkown
HY-N3297 Meranzin hydrate Modulator 99.89% Unkown
HY-171962A KARI 201 hydrochloride Agonist 99.94% Unkown
HY-U00433A JMV 2959 hydrochloride Antagonist 98.09% Unkown
HY-P1155 GRF (1-29) amide (rat) Inducer 99.80% Unkown
HY-P1139 Cortistatin-8 Antagonist 99.56% Unkown
HY-P1421 Obestatin(human) Inhibitor 99.74% Unkown
HY-50760 L-692585 Agonist 98.94% Unkown
HY-N12348 Emoghrelin Activator 95.46% Unkown
HY-12584A (S)-PF-5190457 99.27% Unkown
HY-116625 PF-04628935 Antagonist 99.58% Unkown
HY-P4750 Acetyl-(D-Arg2)-GRF (1-29) amide (human) Antagonist 99.67% Unkown
HY-113906A (αR,8aS)-GSK1614343 Control 99.72% Unkown
HY-P3596A GHRF, mouse TFA Agonist 98.87% Unkown
HY-N3298 Meranzin Modulator 98.0% Unkown
HY-P1547 Somatostatin-25 Inhibitor 96.77% Unkown
HY-P4405 (D-Ala2)-GRF (1-29) amide (human) Agonist 98.83% Unkown
HY-19884A Relamorelin acetate Agonist / Unkown
HY-137061 AZ-GHS-22 Antagonist / Unkown
HY-P1432A K-(D-1-Nal)-FwLL-NH2 TFA Antagonist / Unkown
HY-P10964 Tezusomant Antagonist / Unkown
HY-176995 AZ-GHS-38 Agonist / Unkown
HY-P1432 K-(D-1-Nal)-FwLL-NH2 Antagonist / Unkown
HY-117584 L-163255 free base / Unkown
HY-P1306 Obestatin(rat) 98.73% Unkown
HY-115272 GSK894490A Agonist / Unkown
HY-171962 KARI 201 Agonist / Unkown
HY-P3607 GHRF, bovine Activator / Unkown
HY-186165 KARI 101 Agonist / Unkown
HY-157556 BPP-2 / Unkown
HY-P3056 GHRF, ovine / Unkown
HY-145364 Ghrelin receptor full agonist-2 Agonist / Unkown
HY-100305 Substituted piperidines-1 Agonist / Unkown
HY-P1306A Obestatin(rat) TFA / Unkown
HY-113906 GSK1614343 Antagonist / Unkown
HY-14495A BMS-604992 free base Agonist / Unkown
HY-119125 BMS-317180 Agonist / Unkown
HY-153095 PF-6870961 Agonist / Unkown
HY-P1366A des-​Gln14-​Ghrelin TFA / Unkown
HY-19454 CP-464709 Agonist / Unkown
HY-14495B BMS-604992 dihydrochloride Agonist / Unkown
HY-153095A PF-6870961 hydrochloride Agonist / Unkown
HY-118995 L-739943 Activator / Unkown
HY-P3596 GHRF, mouse / Unkown
HY-14495 BMS-604992 Agonist / Unkown
HY-173271 GHSR-1a agonist-1 Agonist / Unkown
HY-111232 GSK894281 Agonist / Unkown
HY-10957A L-692429 hydrochloride Agonist / Unkown
HY-180210 Ghrelin receptor full agonist-3 Agonist / Unkown
HY-129287 JMV 3008 Antagonist / Unkown
HY-P10673 KwFwLL-NH2 Antagonist / Unkown
HY-129207 JMV 3002 / Unkown
HY-116959 SM-130686 / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GHSR RGD RGD:621397
Felis catus GHSR VGNC VGNC:62548
Canis familiaris GHSR VGNC VGNC:41210
Bos taurus GHSR VGNC VGNC:29352
Mus musculus GHSR MGD MGI:2441906
Macaca mulatta GHSR VGNC VGNC:73051
Others GHSR NCBI