PF-6870961
PF-6870961 is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM.
For research use only. We do not sell to patients.
- CAS No.: 2857112-06-0
- Formula: C29H32N6O2S
- Molecular Weight:528.67
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Satiated and fasted rats model[1]
-
Dosage:2.5 mg/kg, 10 mg/kg, and 40 mg/kg
-
Administration:Intraperitoneal injection
-
Result:Significantly reduced food intake at 40 mg/kg.
Chemical Information
-
CAS No. 2857112-06-0
-
Molecular Weight 528.67
-
Formula C29H32N6O2S
-
SMILES
CC1=CN(C(S1)=N2)C=C2CC(N3CCC4(CC3)CN([C@H]5C6=CC=C(C7=NC(O)=NC(C)=C7)C=C6CC5)C4)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-6870961 Related Classifications
HY-153095 Related Classifications
Powered by Bioz