KwFwLL-NH2

Cat. No.: HY-P10673: Data Sheet Handling Instructions
FAQs
Technical Support

KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC₅₀=45.6 nM).

For research use only. We do not sell to patients.

KwFwLL-NH2 Chemical Structure

CAS No. : 942266-38-8

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All GHSR Isoform Specific Products:

View All Isoforms

GHSR1a

Biological Activity
Purity & Documentation
References
Customer Review

Description

KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC₅₀=45.6 nM)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	IC₅₀	13 nM Compound: KwFwLL-NH2	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	[PMID: 17371869]
COS-7	IC₅₀	19 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	2.6 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	21 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	27 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	29 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	32 nM Compound: KwFwLL-NH2	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	36 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	43 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	60 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	61 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	83 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	> 1000 nM Compound: KwFwLL-NH2	Agonist activity at human ghrelin receptor Asp2:20Asn(Asp99) mutant expressed in african green monkey COS7 cells assessed as inhibition of inositol phosphate accumulation Agonist activity at human ghrelin receptor Asp2:20Asn(Asp99) mutant expressed in african green monkey COS7 cells assessed as inhibition of inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	> 1000 nM Compound: KwFwLL-NH2	Agonist activity at human ghrelin receptor Asp2:20Lys(Asp99) mutant expressed in african green monkey COS7 cells assessed as inhibition of inositol phosphate accumulation Agonist activity at human ghrelin receptor Asp2:20Lys(Asp99) mutant expressed in african green monkey COS7 cells assessed as inhibition of inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	> 1000 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Arg6:20Gln(Arg283) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Arg6:20Gln(Arg283) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	> 1000 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Gln3:05Ala(Gln120) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Gln3:05Ala(Gln120) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	> 1000 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Glu3:09Gln(Glu124) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Glu3:09Gln(Glu124) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	> 1000 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	> 1000 nM Compound: KwFwLL-NH2	Inverse agonist activity at human ghrelin receptor Phe7:09Ala(Phe312) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor Phe7:09Ala(Phe312) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
HEK-293T	EC₅₀	100 nM Compound: KwFwLL-NH2	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	[PMID: 27072910]

Molecular Weight

891.11

Formula

C₄₉H₆₆N₁₀O₆

CAS No.

942266-38-8

Sequence

Lys-{D-Trp}-Phe-{D-Trp}-Leu-Leu-NH2

Sequence Shortening

K-{D-Trp}-F-{D-Trp}-LL-NH2

SMILES

O=C(N[C@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)[C@H](CCCCN)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Els S, et al. An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J Med Chem. 2012 Sep 13;55(17):7437-49. [Content Brief]

KwFwLL-NH2 Related Classifications

Metabolic Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KwFwLL-NH2942266-38-8GHSRGrowth hormone secretagogue receptorGhrelin receptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

KwFwLL-NH2

KwFwLL-NH2 Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All GHSR Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

KwFwLL-NH2 Related Classifications

Molarity Calculator

Dilution Calculator