2. GPCR/G Protein
  3. GHSR
  4. Macimorelin

Macimorelin (EP-1572), a GH secretagogue, is an orally active GHSR agonist. Macimorelin stimulates GH release. Macimorelin can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS).

It is advisable to consider the stable salt form (Macimorelin acetate) that retains the same biological activity.

For research use only. We do not sell to patients.

Macimorelin

Macimorelin Chemical Structure

CAS No. : 381231-18-1

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Macimorelin Related Antibodies

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GHSR1a

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Description

Macimorelin (EP-1572), a GH secretagogue, is an orally active GHSR agonist. Macimorelin stimulates GH release. Macimorelin can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS)[1][2][3].

IC50 & Target

GHSR[1]
In Vivo

Macimorelin (5 mg/kg, i.p. twice daily for 2 weeks) decreases the number and duration of seizures in IHKA mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Intrahippocampal kainic acid (IHKA) mouse model[2]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.), twice daily for 2 weeks.
Result: Significantly decreased the number and duration of seizures during the treatment period, but had no antiepileptogenic or disease-modifying effect.
Clinical Trial
Molecular Weight

474.55

Formula

C26H30N6O3
CAS No.
SMILES

O=CN[C@@H](CC1=CNC2=CC=CC=C12)NC([C@H](NC(C(C)(N)C)=O)CC3=CNC4=CC=CC=C34)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Macimorelin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Macimorelin381231-18-1EP-1572 AEZS-130EP1572EP 1572AEZS130AEZS 130AEZS-130GHSRGrowth hormone secretagogue receptorGhrelin receptorIHKAGHgrowth hormoneAGHDCACSInhibitorinhibitorinhibit

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