Akt3 - AKT serine/threonine kinase 3 Gene

Also Known as Pkbg

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29414

About Akt3

Primary_assembly 13: 88,946,091-89,225,708 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 203 orthologues, 5 paralogues and is associated with 22 phenotypes. Biased expression in Brain (RPKM 538.7), Thymus (RPKM 188.1) and 8 other tissues.

Summary

Enables ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within cellular response to Insulin stimulus and positive regulation of sodium ion transport. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human Akt3 (Akt serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Akt3 Products (1)

mRNA Protein Name
NM_031575.2 NP_113763.2 RAC-gamma serine/threonine-protein kinase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9887206 RGD
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
7488143 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
7488143 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
17715136 RGD
acts upstream of or within positive regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
17715136 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9887206 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Akt3 Protein Structure

PH_PKB

PH_PKB: cd01241 (3 - 132)

PKc_like

PKc_like: cl21453 (174 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

RAC-gamma serine/threonine-protein kinase

  • AKT3 kinase

  • PKB gamma

  • RAC-PK-gamma

  • protein kinase Akt-3

  • protein kinase B, gamma

  • thymoma viral proto-oncogene 3

  • v-akt murine thymoma viral oncogene 3

  • v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-15431 Capivasertib Inhibitor 99.96% Unkown
Inhibitory Antibodies (1)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-P99118 Serplulimab Inducer 99.30% Unkown

Clinical Phase

Bioactive Molecules (13)
Cat. No. 상품명 효과
Purity Phase
HY-15727 Afuresertib Inhibitor 99.53% Phase 3
HY-15186A Ipatasertib dihydrochloride Inhibitor 99.27% Phase 3
HY-15186C Ipatasertib tosylate Inhibitor / Phase 3
HY-19719 Miransertib Inhibitor 99.32% Phase 2
HY-108232 MK-2206 Inhibitor 99.72% Phase 2
HY-15965 Uprosertib Inhibitor 99.93% Phase 2
HY-19934 Pifusertib Inhibitor 99.81% Phase 2
HY-10358 MK-2206 dihydrochloride Inhibitor 99.99% Phase 1
HY-10249 GSK-690693 Inhibitor 99.03% Phase 1
HY-100018 BAY1125976 Inhibitor 99.52% Phase 1
HY-16071 AT13148 Inhibitor 99.20% Phase 1
HY-137458A Vevorisertib trihydrochloride Inhibitor 99.60% Phase 1
HY-100501 M2698 Inhibitor 99.74% Phase 1

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-15186 Ipatasertib Inhibitor 99.88% Yes
HY-10355 AKT inhibitor VIII Inhibitor 98.97% Unkown
HY-10425 Rizavasertib Inhibitor 99.04% Unkown
HY-133120 INY-03-041 Inhibitor 99.74% Unkown
HY-151504 Engasertib Inhibitor 99.65% Unkown
HY-12059 AT7867 Inhibitor 99.85% Unkown
HY-19934A Pifusertib hydrochloride Inhibitor 99.90% Unkown
HY-19982 AKT-IN-6 Inhibitor 99.08% Unkown
HY-15727A Afuresertib hydrochloride Inhibitor 99.95% Yes
HY-19719A Miransertib hydrochloride Inhibitor 99.74% Yes
HY-145282 MS170 Inhibitor 98.68% Unkown
HY-12059A AT7867 dihydrochloride Inhibitor 99.73% Unkown
HY-137458 Vevorisertib Inhibitor 98.03% Unkown
HY-133120A INY-03-041 trihydrochloride Inhibitor 99.78% Unkown
HY-132302 Hu7691 Inhibitor 99.91% Unkown
HY-129119 Akt1/Akt2-IN-2 Inhibitor 98.57% Unkown
HY-151613 MS15 Inhibitor / Unkown
HY-126257 AKT-IN-3 Inhibitor 98.12% Unkown
HY-143883 MS143 Degrader 97.8% Unkown
HY-132302A Hu7691 free base Inhibitor / Unkown
HY-145281 MS98 Inhibitor / Unkown
HY-10357 MK-2206 free base Inhibitor / Unkown
HY-175976 Akt3 ligand-1 Inhibitor / Unkown
HY-175975 PROTAC Akt3 Degrader-1 Degrader / Unkown
HY-143611 AKT-IN-8 Inhibitor / Unkown
HY-16032 Akt1-IN-2 Inhibitor 99.83% Unkown
HY-15965A Uprosertib hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akt3 NCBI NCBI:10000