AKT3 - AKT serine/threonine kinase 3 Gene

Also Known as MPPH; PKBG; MPPH2; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10000

About AKT3

Cytogenetic location: 1q43-q44 Genomic coordinates (GRCh38): 1:243,488,233-243,851,079 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 203 orthologues, 5 paralogues and is associated with 91 phenotypes. Ubiquitous expression in brain (RPKM 16.6), ovary (RPKM 12.6) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the Akt, also called PKB, serine/threonine protein kinase family. Akt kinases are known to be regulators of cell signaling in response to Insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, Apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), Insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

AKT3 Products (13)

mRNA	Protein	Name
XM_047415643.1	XP_047271599.1	RAC-gamma serine/threonine-protein kinase isoform X1
XM_047420641.1	XP_047276597.1	RAC-gamma serine/threonine-protein kinase isoform X2
XM_047417359.1	XP_047273315.1	RAC-gamma serine/threonine-protein kinase isoform X2
NM_001206729.2	NP_001193658.1	RAC-gamma serine/threonine-protein kinase isoform 2
NM_001370074.1	NP_001357003.1	RAC-gamma serine/threonine-protein kinase isoform 1
XM_047419186.1	XP_047275142.1	RAC-gamma serine/threonine-protein kinase isoform X2
XM_011544014.3	XP_011542316.1	RAC-gamma serine/threonine-protein kinase isoform X4
XM_047424332.1	XP_047280288.1	RAC-gamma serine/threonine-protein kinase isoform X2
XM_024446892.2	XP_024302660.1	RAC-gamma serine/threonine-protein kinase isoform X3
NM_181690.2	NP_859029.1	RAC-gamma serine/threonine-protein kinase isoform 2
XM_024447938.2	XP_024303706.1	RAC-gamma serine/threonine-protein kinase isoform X5
XM_047422391.1	XP_047278347.1	RAC-gamma serine/threonine-protein kinase isoform X2
NM_005465.7	NP_005456.1	RAC-gamma serine/threonine-protein kinase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16540465	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12176997	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	16540465	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitochondrial genome maintenance	IMP IMP: Inferred from mutant phenotype	18524868	GOA
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	25323119	GOA
involved in positive regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	28254819	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	25323119	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	25323119	GOA
involved in positive regulation of vascular endothelial cell proliferation	IDA IDA: Inferred from direct assay	28254819	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	18524868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKT3 Protein Structure

Pkinase

Pkinase_C

0
100
200
300
400
479 a.a.

Protein Preferred Names	Protein Names
RAC-gamma serine/threonine-protein kinase	PKB gamma RAC-gamma serine/threonine protein kinase v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

AKT3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AKT3	Q9Y243	TTC3	Homo sapiens	P53804	Anti Bait CoIP	20059950
Intra	AKT3	Q9Y243	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	33961781
Intra	AKT3	Q9Y243	HSP90AA1	Homo sapiens	P07900	Lumier	25036637
Intra	AKT3	Q9Y243	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AKT3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75519	AKT3 Protein, Human (Inactive, sf9, GST)	Q9Y243-1 (M1-E479)	≥ 90%, as determined by reducing SDS-PAGE.

AKT3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80009	AKT1/2/3 Antibody (YA633)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
HY-P80535	AKT1+AKT2+AKT3 Antibody (YA635)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
HY-P80535A	AKT1+AKT2+AKT3 Antibody (YA635)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
HY-P84883	AKT3 Antibody (YA4580)	ICC/IF, FC, ELISA	Human
HY-P84883A	AKT3 Antibody (YA4580)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P85759	AKT Antibody (YA5451)	WB, IP, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86145	Phospho-AKT(Thr308) Antibody (YA5837) (YA5837)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86312	AKT1/2/3 Antibody (YA6004)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86450	Phospho-AKT(Ser473) Antibody (YA6142) (YA6142)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2	MPPH2 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome, Type 2
Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome	Megalencephaly-Capillary Malformation Syndrome MCAP Mcmtc Macrocephaly-Capillary Malformation Mcm Megalencephaly Cutis Marmorata Telangiectatica Congenita Macrocephaly-Cutis Marmorata Telangiectatica Congenita Megalencephaly-Cutis Marmorata Telangiectatica Congenita Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome, Somatic M-Cm Macrocephaly Cutis Marmorata Telangiectatica Congenita Macrocephaly-Capillary Malformation Syndrome M-Cmtc Megalocephaly Cutis Marmorata Telangiectatica Congenita Macrocephaly-Cutis Marmorata Telangiectatica Congenita Syndrome Megalencephaly-Cutis Marmorata Telangiectatica Congenita Syndrome
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 CMM1 Melanoma, Cutaneous Malignant Cmm Melanoma, Malignant Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Megacolon	Dilatation Of Colon
Glioma
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Colon Leiomyoma	Colonic Leiomyoma
Nevus, Epidermal	Epidermal Nevus Woolly Hair Nevus Epidermal Naevus Epidermal Nevus Syndrome Nevus, Keratinocytic, Nonepidermolytic Epidermal Nevus, Somatic Nevus, Epidermal, Somatic Nevus Sebaceous Or Woolly Hair Nevus, Somatic Nonepidermolytic Keratinocytic Nevus Epidermal Hamartoma Syndrome Wooly Hair Nevus Keratinocytic Non-Epidermolytic Nevus KNEN Pigmented Moles Organoid Nevus Phakomatosis Nevus Sebaceous Melanocytic Nevus Melanocytic Nevus Of Skin
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Hypoinsulinemic Hypoglycemia With Hemihypertrophy	Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy HIHGHH
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Congenital Megacolon Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against Hirschsprung'S Disease Congenital Intestinal Aganglionosis HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Polydactyly	Non-Syndromic Polydactyly Polydactyly, Postaxial Postaxial Polydactyly Supernumerary Digit Extra Digits Hyperdactyly Polydactylia Polydactylism Supernumerary Digits
Hemimegalencephaly	Unilateral Megalencephaly Macrencephaly
Bardet-Biedl Syndrome 16	BBS16 Bardet-Biedl Syndrome, Type 16
Klippel-Trenaunay-Weber Syndrome	Klippel-Trenaunay Syndrome KTS Ktw Syndrome Angioosteohypertrophy Syndrome Angio-Osteohypertrophy Syndrome Klippel Trenaunay Syndrome Klippel-Trénaunay-Weber Syndrome Haemangiectatic Hypertrophy Weber-Klippel-Trenaunay Congenital Dysplastic Angiopathy Klippel-Trenaunay Disease Weber Klippel Trenaunay
Cowden Syndrome 1	Pten Hamartoma Tumor Syndrome Bannayan-Riley-Ruvalcaba Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Lhermitte-Duclos Syndrome Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Periventricular Nodular Heterotopia	Periventricular Heterotopia Pvnh Familial Nodular Heterotopia Heterotopia, Periventricular Periventricular Heterotopia, X-Linked
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Corneal Dystrophy, Fleck	Fleck Corneal Dystrophy Fcd CFD Corneal Fleck Dystrophy Francois-Neetens Speckled Corneal Dystrophy Corneal Dystrophy, Francois-Neetens Speckled Or Flecked Corneal Dystrophy Francois-Neetens Speckled Or Flecked Dystrophy, Corneal, Fleck
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Megalencephaly	Macroencephaly Macrencephaly
Senior-Loken Syndrome 7	SLSN7 Senior-Loken Syndrome, Type 7
Band Heterotopia	Subcortical Band Heterotopia Double Cortex Syndrome Subcortical Laminar Heterotopia Double Cortex Band Heterotopia Of Brain BH Heco Heterotopic Cortex Familial Band Heterotopia Dc Dc Syndrome Heterotopia, Subcortical Band Sbh Sclh Bhy
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Autosomal Dominant Intellectual Developmental Disorder 19	Autosomal Dominant Non-Syndromic Intellectual Disability 19 Autosomal Dominant Mental Retardation 19 Mrd19
Thymoma	Primary Thymic Epithelial Neoplasm Primary Thymic Epithelial Tumor Thymus Neoplasms
Proteus Syndrome	Proteus Syndrome, Somatic Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly Wiedemann'S Syndrome Hemihypertrophy And Macrocephaly Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly Ps PROTEUSS Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly
Hypomelanosis Of Ito	Incontinentia Pigmenti Achromians Nevus Of Ito Ipa Ito Hypomelanosis Ito Pigmentation Disorders HMI Incontinentia Pigmenti, Type I, Formerly Ip1, Formerly Bloch-Siemans Syndrome Incontinentia Pigmenti Achromians Syndrome Ito'S Nevus Incontinentia Pigmenti Type 1 Nevi Of Ito Nevus Fuscocaeruleus Acromiodeltoideus Bloch Sulzberger Syndrome Skin Pigmentation Disorder
Polymicrogyria, Bilateral Perisylvian, X-Linked	Bilateral Perisylvian Polymicrogyria Polymicrogyria, Bilateral Perisylvian Pmgx Perisylvian Syndrome, Congenital Bilateral Cbps Congenital Bilateral Perisylvian Syndrome Perisylvian Syndrome BPPX Bpp
Capillary Hemangioma	Strawberry Nevus Of Skin Cellular Hemangioma Of Infancy Congenital Vascular Hamartoma Congenital Vascular Naevus Infantile Hemangioma Juvenile Hemangioma Strawberry Haemangioma Strawberry Nevus Hemangioma Capillary Hemangioma, Capillary Hemangioma, Cavernous
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1	Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Mpph Syndrome Mpph MPPH1 Meg-Pmg-Megacc Syndrome Megalencephaly-Polymicrogyria-Postaxial Polydactyly-Hydrocephalus Syndrome Megalencephaly, Polymicrogyria, Mega Corpus Callosum Syndrome Megalencephaly, Mega Corpus Callosum, And Complete Lack Of Motor Development Megalencephaly And Perisylvian Polymicrogyria With Postaxial Polydactyly And Hydrocephalus Megalencephaly, Polymicrogyria, And Hydrocephalus Syndrome Meg-Pmg-Poly-Hyd Megalencephaly-Postaxial Polydactyly-Polymicrogyria-Hydrocephalus Syndrome Megalencephaly Mega Corpus Callosum And Complete Lack Of Motor Development Megalencephaly-Polymicrogyria-Mega Corpus Callosum Syndrome Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome, Type 1 Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome
Polymicrogyria	Pmg
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi	Cloves Syndrome Clove Syndrome Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, And Skeletal/Spinal Abnormalities Clove Syndrome, Somatic Congenital Lipomatous Overgrowth - Vascular Malformation - Epidermal Nevi Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Skeletal Anomaly Syndrome Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Spinal Anomaly Syndrome CLOVE Congenital Lipomatous Overgrowth Vascular Malformations Epidermal Nevi And Skeletal/Spinal Abnormalities Congenital Arteriovenous Malformation Arteriovenous Hemangioma Nevus Melanocytic Nevus Benign Melanocytic Nevus
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Macrocephaly/Autism Syndrome	Macrocephaly-Autism Syndrome Macrocephaly-Intellectual Disability-Autism Syndrome MCEPHAS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15431	Capivasertib	Inhibitor	99.96%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99118	Serplulimab	Inducer	99.30%	Unkown

Clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15727	Afuresertib	Inhibitor	99.53%	Phase 3
HY-15186A	Ipatasertib dihydrochloride	Inhibitor	99.27%	Phase 3
HY-15186C	Ipatasertib tosylate	Inhibitor	/	Phase 3
HY-19719	Miransertib	Inhibitor	99.32%	Phase 2
HY-108232	MK-2206	Inhibitor	99.72%	Phase 2
HY-15965	Uprosertib	Inhibitor	99.93%	Phase 2
HY-19934	Pifusertib	Inhibitor	99.81%	Phase 2
HY-10358	MK-2206 dihydrochloride	Inhibitor	99.99%	Phase 1
HY-10249	GSK-690693	Inhibitor	99.03%	Phase 1
HY-100018	BAY1125976	Inhibitor	99.52%	Phase 1
HY-16071	AT13148	Inhibitor	99.20%	Phase 1
HY-137458A	Vevorisertib trihydrochloride	Inhibitor	98.05%	Phase 1
HY-100501	M2698	Inhibitor	99.74%	Phase 1

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15186	Ipatasertib	Inhibitor	99.88%	Yes
HY-10355	AKT inhibitor VIII	Inhibitor	98.97%	Unkown
HY-10425	Rizavasertib	Inhibitor	99.04%	Unkown
HY-133120	INY-03-041	Inhibitor	99.74%	Unkown
HY-151504	Engasertib	Inhibitor	99.65%	Unkown
HY-12059	AT7867	Inhibitor	99.85%	Unkown
HY-19934A	Pifusertib hydrochloride	Inhibitor	99.90%	Unkown
HY-19982	AKT-IN-6	Inhibitor	99.08%	Unkown
HY-15727A	Afuresertib hydrochloride	Inhibitor	99.95%	Yes
HY-19719A	Miransertib hydrochloride	Inhibitor	99.74%	Yes
HY-145282	MS170	Inhibitor	98.68%	Unkown
HY-12059A	AT7867 dihydrochloride	Inhibitor	99.73%	Unkown
HY-137458	Vevorisertib	Inhibitor	98.03%	Unkown
HY-133120A	INY-03-041 trihydrochloride	Inhibitor	99.78%	Unkown
HY-132302	Hu7691	Inhibitor	99.91%	Unkown
HY-129119	Akt1/Akt2-IN-2	Inhibitor	98.57%	Unkown
HY-151613	MS15	Inhibitor	/	Unkown
HY-126257	AKT-IN-3	Inhibitor	98.12%	Unkown
HY-143883	MS143	Degrader	97.8%	Unkown
HY-132302A	Hu7691 free base	Inhibitor	/	Unkown
HY-145281	MS98	Inhibitor	/	Unkown
HY-10357	MK-2206 free base	Inhibitor	/	Unkown
HY-175976	Akt3 ligand-1	Inhibitor	/	Unkown
HY-175975	PROTAC Akt3 Degrader-1	Degrader	/	Unkown
HY-143611	AKT-IN-8	Inhibitor	/	Unkown
HY-16032	Akt1-IN-2	Inhibitor	99.83%	Unkown
HY-15965A	Uprosertib hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AKT3	VGNC	VGNC:59729
Rattus norvegicus	AKT3	RGD	RGD:62390
Macaca mulatta	AKT3	VGNC	VGNC:69778
Mus musculus	AKT3	MGD	MGI:1345147
Canis familiaris	AKT3	VGNC	VGNC:37773
Bos taurus	AKT3	VGNC	VGNC:25800
Others	AKT3	NCBI