Cyp11a1 - cytochrome P450, family 11, subfamily a, polypeptide 1 Gene

Also Known as Cyp11a; Cypxia1; P450scc; P450(scc)

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29680

Summary

Enables Cholesterol binding activity and Cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including nervous system development; response to vitamin; and steroid biosynthetic process. Located in mitochondrial crista and perikaryon. Biomarker of several diseases, including glucose metabolism disease (multiple); hypertension; nephrosis; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (Cytochrome P450 family 11 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp11a1 Products (1)

mRNA Protein Name
NM_017286.3 NP_058982.1 cholesterol side-chain cleavage enzyme, mitochondrial precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in C21-steroid hormone biosynthetic process IDA
IDA: Inferred from direct assay
19665544 RGD
involved in Leydig cell differentiation IEP
IEP: Inferred from expression pattern
18502897 RGD
involved in Schwann cell differentiation IEP
IEP: Inferred from expression pattern
18373277 RGD
involved in biphenyl metabolic process IEP
IEP: Inferred from expression pattern
19071209 RGD
involved in cellular response to antibiotic IEP
IEP: Inferred from expression pattern
18655822 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
17719163 RGD
involved in cellular response to cadmium ion IEP
IEP: Inferred from expression pattern
17719163 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
17494997 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
20810564 RGD
involved in cellular response to gonadotropin stimulus IEP
IEP: Inferred from expression pattern
9397943 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
9397943 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
20665543 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
19416745 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
18511507 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
9397943 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
16329132 RGD
involved in dibenzo-p-dioxin metabolic process IEP
IEP: Inferred from expression pattern
18637154 RGD
involved in granulosa cell differentiation IEP
IEP: Inferred from expression pattern
2176216 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
21047951 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
18772241 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
17726144 RGD
involved in mating behavior IMP
IMP: Inferred from mutant phenotype
16101892 RGD
involved in organic acid metabolic process IEP
IEP: Inferred from expression pattern
17400581 RGD
involved in phenol-containing compound metabolic process IEP
IEP: Inferred from expression pattern
18191889 RGD
involved in phthalate metabolic process IEP
IEP: Inferred from expression pattern
18923996 RGD
involved in response to L-ascorbic acid IEP
IEP: Inferred from expression pattern
17280759 RGD
involved in response to alkaloid IEP
IEP: Inferred from expression pattern
18772241 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
18040670 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
2176216 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
15223132 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
18335507 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
12715917 RGD
involved in response to fungicide IEP
IEP: Inferred from expression pattern
14967917 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
18046538 RGD
involved in response to genistein IEP
IEP: Inferred from expression pattern
16214947 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
19929576 RGD
involved in response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
14635199 RGD
involved in response to insecticide IEP
IEP: Inferred from expression pattern
19892000 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
18821396 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
16844298 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18606229 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
18609294 RGD
involved in response to salt stress IEP
IEP: Inferred from expression pattern
7678819 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
19961867 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
17280759 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20144211 RGD
involved in steroid biosynthetic process IMP
IMP: Inferred from mutant phenotype
17218406 RGD
involved in testosterone biosynthetic process IEP
IEP: Inferred from expression pattern
19883722 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial crista IDA
IDA: Inferred from direct assay
11691658 RGD
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
21075169 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
2170421 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
16632873 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cholesterol side-chain cleavage enzyme, mitochondrial

  • cholesterol desmolase

  • cholesterol side-chain cleavage cytochrome P450

  • cytochrome P450 11A1

  • cytochrome P450 11a cholesterol side chain cleavage

  • cytochrome P450 family 11 subfamily a

  • cytochrome P450 side-chain cleavage enzyme

  • cytochrome P450 subfamily

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16276 Osilodrostat Inhibitor 99.82% Yes
HY-16276A Osilodrostat phosphate Inhibitor 98.83% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-156628 Opevesostat Inhibitor 99.79% Phase 3
HY-B0105B Levoketoconazole Inhibitor 99.82% Phase 3

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130705A Tachysterol 3 99.68% Unkown
HY-103322 6-Bnz-cAMP sodium salt 98.5% Unkown
HY-156530 CYP11A1-IN-1 Inhibitor 98.90% Unkown
HY-W679754 Pentacosafluorotridecanoic Acid Inhibitor 95.0% Unkown
HY-101217 BI 689648 Inhibitor 99.20% Unkown
HY-135281 CYP11B2-IN-1 Inhibitor 99.83% Unkown
HY-122744 CYP11B1-IN-1 Inhibitor / Unkown
HY-151140 CYP11B1-IN-2 Inhibitor / Unkown
HY-176480 CYP11B2-IN-3 Inhibitor / Unkown
HY-179686 CYP11A1-IN-2 Inhibitor / Unkown
HY-181747 CYP11A1-IN-3 Inhibitor / Unkown
HY-RS03434 CYP11A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03435 CYP11B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-163751 STING-IN-9 Inhibitor / Unkown
HY-RS17315 Cyp11b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17479 Cyp11a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23770 Cyp11b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23937 Cyp11a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp11a1 NCBI NCBI:1583