Sirt5 - sirtuin 5 Gene

Rattus norvegicus

Gene ID: 306840 | Gene type: protein coding

About Sirt5

Primary_assembly 17: 21,310,028-21,337,101 reverse strand.mRatBN7.2:CM026990.1

This gene has 1 transcript (splice variant), 265 orthologues and 6 paralogues. Biased expression in Heart (RPKM 365.5), Brain (RPKM 277.9) and 9 other tissues.

Summary

Predicted to enable NAD+ binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and zinc ion binding activity. Involved in negative regulation of cardiac muscle cell apoptotic process and response to nutrient levels. Predicted to be located in mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial matrix. Predicted to be active in cytosol and mitochondrion. Orthologous to human SIRT5 (Sirtuin 5). [provided by Alliance of Genome Resources, Apr 2022]

Sirt5 Products(1)

mRNA	Protein	Name
NM_001004256.1	NP_001004256.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial

Sirt5 Protein Structure

SIRT5_Af1_CobB

0
100
200
310 a.a.

Protein Preferred Names

Protein Names

NAD-dependent protein deacylase sirtuin-5, mitochondrial

NAD-dependent deacetylase sirtuin-5	NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
SIR2-like protein 5	regulatory protein SIR2 homolog 5

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0879A	Suramin sodium salt	Inhibitor	99.48%	Yes
HY-B0879	Suramin	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146387	SIRT5 inhibitor 3	Inhibitor	≥98.0%	Unkown
HY-145651	Et-29	Inhibitor	99.89%	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	/	Unkown
HY-152214	SIRT5 inhibitor 5	Inhibitor	/	Unkown
HY-146386	SIRT5 inhibitor 2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sirt5	NCBI	NCBI:23408

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