2. Gene
  3. ITGB8 - integrin subunit beta 8 Gene

ITGB8 - integrin subunit beta 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 3696 | Gene type: protein coding

About ITGB8

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:20,329,766-20,415,754 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues and 8 paralogues. Broad expression in kidney (RPKM 12.1), brain (RPKM 11.6) and 19 other tissues.

Summary

This gene is a member of the Integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric Integrin complex. In general, Integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

ITGB8 Products(1)

mRNA Protein Name
NM_002214.3 NP_002205.1 integrin beta-8 precursor

ITGB8 Protein Structure

Integrin_beta

Integrin_beta: Integrin beta chain VWA domain (54 - 469)

EGF_2

EGF_2: EGF-like domain (553 - 583)

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  • 769 a.a.
Protein Preferred Names Protein Names

integrin beta-8

Recombinant ITGB8 Proteins

Cat. No. Product Name Accession Purity
HY-P72535 Integrin alpha V beta 8 Protein, Human (HEK293, His) P06756 (F31-V992)&P26012 (E43-R684) ≥95%
HY-P73865 Integrin alpha V beta 8 Protein, Human (HEK293, His, solution) P06756 (F31-V992)&P26012 (E43-R684) ≥95%
HY-P77722 Integrin alpha V beta 8 Protein, Human (HEK293, His-Avi) P06756 (F31-V992)&P26012 (E43-R684) ≥95%

Related Diseases

Diseases Alias
Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia

Arvc

Arvd

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Arvc Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

Arvd/C

Right Ventricular Dysplasia, Arrhythmogenic

Ventricular Dysplasia, Right, Arrhythmogenic

Cardiomyopathy, Ventricular, Right, Arrhythmogenic

Dysplasia, Arrhythmogenic Right Ventricular
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06972 ITGB8 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ITGB8 VGNC VGNC:73791
Felis catus ITGB8 VGNC VGNC:67857
Mus musculus ITGB8 MGD MGI:1338035
Rattus norvegicus ITGB8 RGD RGD:1311374
Bos taurus ITGB8 VGNC VGNC:30333
Canis familiaris ITGB8 VGNC VGNC:42143
Others ITGB8 NCBI