ITGB8 - integrin subunit beta 8 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3696

About ITGB8

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:20,329,766-20,415,754 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues and 8 paralogues. Broad expression in kidney (RPKM 12.1), brain (RPKM 11.6) and 19 other tissues.

Summary

This gene is a member of the Integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric Integrin complex. In general, Integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

ITGB8 Products (1)

mRNA	Protein	Name
NM_002214.3	NP_002205.1	integrin beta-8 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables extracellular matrix protein binding	IDA IDA: Inferred from direct assay	7525578	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	24312400	GOA
NOT involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	7525578	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	11970960	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24312400	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	25801897	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24312400	GOA
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	12050137	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	1918072	GOA
part of integrin alphav-beta8 complex	IDA IDA: Inferred from direct assay	1918072	GOA
part of integrin alphav-beta8 complex	IPI IPI: Inferred from physical interaction	30061598	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB8 Protein Structure

Integrin_beta

EGF_2

0
200
400
600
769 a.a.

Protein Preferred Names	Protein Names
integrin beta-8

Recombinant ITGB8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72535	Integrin alpha V beta 8 Protein, Human (HEK293, His)	P06756-1 (F31-V992)&P26012-1 (E43-R684)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73865	Integrin alpha V beta 8 Protein, Human (HEK293, His, solution)	P06756-1 (F31-V992)&P26012-1 (E43-R684)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77722	Integrin alpha V beta 8 Protein, Human (HEK293, His-Avi)	P06756-1 (F31-V992)&P26012-1 (E43-R684)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06972	ITGB8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17983	Itgb8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24454	Itgb8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ITGB8	VGNC	VGNC:73791
Felis catus	ITGB8	VGNC	VGNC:67857
Mus musculus	ITGB8	MGD	MGI:1338035
Rattus norvegicus	ITGB8	RGD	RGD:1311374
Bos taurus	ITGB8	VGNC	VGNC:30333
Canis familiaris	ITGB8	VGNC	VGNC:42143
Others	ITGB8	NCBI