LGALS8 - galectin 8 Gene

Also Known as Gal-8; PCTA1; PCTA-1; Po66-CBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3964

About LGALS8

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:236,518,214-236,552,981 (from NCBI)

This gene has 28 transcripts (splice variants), 279 orthologues and 16 paralogues. Ubiquitous expression in spleen (RPKM 17.5), skin (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a member of the Galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, Apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

LGALS8 Products (4)

mRNA	Protein	Name
NM_006499.5	NP_006490.3	galectin-8 isoform a
NM_201543.4	NP_963837.1	galectin-8 isoform b
NM_201544.4	NP_963838.1	galectin-8 isoform b
NM_201545.2	NP_963839.1	galectin-8 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables carbohydrate binding	IDA IDA: Inferred from direct assay	22246324	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	19268462	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	28077878	GOA
involved in lymphatic endothelial cell migration	IDA IDA: Inferred from direct assay	19268462	GOA
involved in xenophagy	IMP IMP: Inferred from mutant phenotype	22246324	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19268462	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22246324	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGALS8 Protein Structure

Gal-bind_lectin

0
100
200
300
317 a.a.

Protein Preferred Names	Protein Names
galectin-8	Po66 carbohydrate binding protein

LGALS8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LGALS8	O00214	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	LGALS8	O00214	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	25416956
Intra	LGALS8	O00214	TAX1BP1	Homo sapiens	Q86VP1	Anti Tag CoIP	33961781
Intra	LGALS8	O00214	TGIF1	Homo sapiens	Q15583	IF	18511908
Intra	LGALS8	O00214	TGIF1	Homo sapiens	Q15583	Anti Bait CoIP	18511908
Intra	LGALS8	O00214	TGIF1	Homo sapiens	Q15583	Anti Tag CoIP	18511908
Intra	LGALS8	O00214	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	LGALS8	O00214	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	LGALS8	O00214	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	LGALS8	O00214	APEH	Homo sapiens	P13798	Validated Y2H	25416956
Intra	LGALS8	O00214	APEH	Homo sapiens	P13798	Y2H Array	31515488
Intra	LGALS8	O00214	CALCOCO2	Homo sapiens	Q13137	Y2H Pooling	16189514
Intra	LGALS8	O00214	CALCOCO2	Homo sapiens	Q13137	Anti Tag CoIP	33961781
Intra	LGALS8	O00214	CALCOCO2	Homo sapiens	Q13137	Y2H Array	31515488
Intra	LGALS8	O00214	CALCOCO2	Homo sapiens	Q13137	Anti Tag CoIP	28514442
Intra	LGALS8	O00214	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	LGALS8	O00214	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	LGALS8	O00214	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	LGALS8	O00214	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	LGALS8	O00214	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LGALS8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70190	Galectin-8/LGALS8 Protein, Human	O00214-1 (M1-W317)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700081AF	Animal-Free Galectin-8/LGALS8 Protein, Human (His)	O00214-1 (M2-W317)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700382	Galectin-8/LGALS8 Protein, Human (GST)	O00214-1 (M1-W317)	≥ 90%, as determined by reducing SDS-PAGE.

LGALS8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82441	Galectin 8 Antibody (YA2186)	WB, IHC-P, ICC/IF, IP, FC	Human

Related Diseases

Diseases	Alias
Prostatic Hypertrophy	Benign Prostatic Hypertrophy Prostatic Hyperplasia
Cholesteatoma Of Middle Ear	Cholesteatoma Epidermosis Of Ear Epidermosis Of Middle Ear Middle Ear Cholesteatoma Cholesteatoma Of Middle Ear And Mastoid Cholesteatoma Of Middle Ear And/Or Mastoid Cholesteatoma Of The Middle Ear Congenital Cholesteatoma Primary Acquired Cholesteatoma Secondary Acquired Cholesteatoma Cholesteatoma Middle Ear Cholesteatoma, Middle Ear Cholesterolosis Of Middle Ear Cholesterosis Of Ear Cholesterosis Of Middle Ear Cholesteatoma Nos Epidermoid Cholesteatoma Middle Ear Granuloma
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07609	LGALS8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19513	Lgals8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26007	Lgals8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LGALS8	RGD	RGD:621272
Macaca mulatta	LGALS8	VGNC	VGNC:74258
Canis familiaris	LGALS8	VGNC	VGNC:42650
Bos taurus	LGALS8	VGNC	VGNC:30855
Mus musculus	LGALS8	MGD	MGI:1928481
Others	LGALS8	NCBI