LGALS8 - galectin 8 Gene

Homo sapiens

Also known as Gal-8; PCTA1; PCTA-1; Po66-CBP

Gene ID: 3964 | Gene type: protein coding

About LGALS8

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:236,518,214-236,552,981 (from NCBI)

This gene has 28 transcripts (splice variants), 279 orthologues and 16 paralogues. Ubiquitous expression in spleen (RPKM 17.5), skin (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a member of the Galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, Apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

LGALS8 Products(4)

mRNA	Protein	Name
NM_006499.5	NP_006490.3	galectin-8 isoform a
NM_201543.4	NP_963837.1	galectin-8 isoform b
NM_201544.4	NP_963838.1	galectin-8 isoform b
NM_201545.2	NP_963839.1	galectin-8 isoform a

LGALS8 Protein Structure

Gal-bind_lectin

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

galectin-8

Po66 carbohydrate binding protein

Recombinant LGALS8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70190	Galectin-8/LGALS8 Protein, Human	O00214 (M1-W317)	≥95%
HY-P700081AF	Animal-Free Galectin-8/LGALS8 Protein, Human (His)	O00214 (M2-W317)	≥95%
HY-P700382	Galectin-8/LGALS8 Protein, Human (GST)	O00214 (M1-W317)	≥95%

Related Diseases

Diseases

Alias

Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia

Cholesteatoma Of Middle Ear

Cholesteatoma	Epidermosis Of Ear
Epidermosis Of Middle Ear	Middle Ear Cholesteatoma
Cholesteatoma Of Middle Ear And Mastoid	Cholesteatoma Of Middle Ear And/Or Mastoid
Cholesteatoma Of The Middle Ear	Congenital Cholesteatoma
Primary Acquired Cholesteatoma	Secondary Acquired Cholesteatoma
Cholesteatoma Middle Ear	Cholesteatoma, Middle Ear
Cholesterolosis Of Middle Ear	Cholesterosis Of Ear
Cholesterosis Of Middle Ear	Cholesteatoma Nos
Epidermoid Cholesteatoma	Middle Ear Granuloma

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07609	LGALS8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LGALS8	RGD	RGD:621272
Macaca mulatta	LGALS8	VGNC	VGNC:74258
Canis familiaris	LGALS8	VGNC	VGNC:42650
Bos taurus	LGALS8	VGNC	VGNC:30855
Mus musculus	LGALS8	MGD	MGI:1928481
Others	LGALS8	NCBI

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