LUM - lumican Gene

Also Known as LDC; SLRR2D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4060

About LUM

Cytogenetic location: 12q21.33 Genomic coordinates (GRCh38): 12:91,102,629-91,111,494 (from NCBI)

This gene has 3 transcripts (splice variants), 199 orthologues and 10 paralogues. Broad expression in gall bladder (RPKM 981.2), urinary bladder (RPKM 643.2) and 14 other tissues.

Summary

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds Collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate Collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

LUM Products (1)

mRNA	Protein	Name
NM_002345.4	NP_002336.1	lumican precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding	IDA IDA: Inferred from direct assay	10892350	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25304424	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of fibrillar collagen trimer	IDA IDA: Inferred from direct assay	10734230	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LUM Protein Structure

LRRNT

LRR_8

0
100
200
300
338 a.a.

Protein Preferred Names	Protein Names
lumican	KSPG lumican

LUM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LUM	P51884	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	LUM	P51884	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	LUM	P51884	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	LUM	P51884	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	LUM	P51884	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	LUM	P51884	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	LUM	P51884	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	LUM	P51884	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	LUM	P51884	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	LUM	P51884	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	LUM	P51884	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	LUM	P51884	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	LUM	P51884	MMP14	Homo sapiens	P50281	Enzymatic Study	25304424
Intra	LUM	P51884	MMP14	Homo sapiens	P50281	SPR	25304424

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LUM Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70369	Lumican/LUM Protein, Human (HEK293, His)	P51884 (Q19-N338)	≥ 95%, as determined by reducing SDS-PAGE.

LUM Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86951	Lumican Antibody (YA6644)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cornea Plana	Flat Cornea
Macular Dystrophy, Corneal	Macular Corneal Dystrophy MCD Corneal Dystrophy, Macular Type Groenouw Type Ii Corneal Dystrophy Fehr Corneal Dystrophy Macular Dystrophy, Corneal Type 1 Mcdc1 Macular Corneal Dystrophy Type Ii Macular Corneal Dystrophy, Type Ii Macular Corneal Dystrophy, Type I Mcdc1, Formerly Macular Dystrophy, Corneal, 1 Macular Corneal Dystrophy Type 1 Corneal Dystrophy Groenouw Type Ii Corneal Dystrophy Macular Type Macular Corneal Dystrophy Type I Dystrophy, Macular, Corneal
Corneal Dystrophy, Posterior Amorphous	Posterior Amorphous Corneal Dystrophy PACD Chromosome 12q21.33 Deletion Syndrome Posterior Amorphous Stromal Dystrophy
Degenerative Myopia	Pathological Myopia Myopia, Degenerative Degenerative Progressive High Myopia Progressive High Myopia Progressive High Myopia
Stromal Dystrophy
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Corneal Ectasia
Corneal Dystrophy, Congenital Stromal	Congenital Stromal Corneal Dystrophy CSCD Congenital Hereditary Stromal Dystrophy Congenital Hereditary Stromal Dystrophy Of The Cornea Congenital Stromal Dystrophy Of The Cornea Dacs Decorin-Associated Congenital Stromal Corneal Dystrophy Dystrophia Corneae Parenchymatosa Congenita Witschel Dystrophy Dystrophy, Corneal, Stromal, Congenital
Refractive Error	Refractive Errors
Corneal Disease	Corneal Diseases Corneal Disorders
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]
Fuchs' Endothelial Dystrophy	Fuchs Endothelial Corneal Dystrophy Fuchs Endothelial Dystrophy Fuchs Dystrophy Fced Fuchs' Corneal Dystrophy Fuchs' Endothelial Corneal Dystrophy Fuchs Atrophy Fuchs Corneal Dystrophy Endoepithelial Corneal Dystrophy Fecd Late Hereditary Endothelial Dystrophy Corneal Dystrophy, Fuchs Endothelial Dystrophy, Corneal, Fuchs Endothelial Corneal Dystrophy, Fuchs' Endothelial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16747	Maralixibat chloride	Inhibitor	99.61%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101190	Volixibat		99.76%	Phase 2
HY-163539A	Pegulicianine		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101190A	(3R,4S,5S)-Volixibat		99.14%	Unkown
HY-RS07891	LUM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17525	Lum Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23982	Lum Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LUM	VGNC	VGNC:31081
Rattus norvegicus	LUM	RGD	RGD:620984
Felis catus	LUM	VGNC	VGNC:68109
Mus musculus	LUM	MGD	MGI:109347
Canis familiaris	LUM	VGNC	VGNC:42865
Macaca mulatta	LUM	VGNC	VGNC:100076
Others	LUM	NCBI