2. Membrane Transporter/Ion Channel
  3. Apical Sodium-Dependent Bile Acid Transporter
  4. Maralixibat chloride

Maralixibat chloride  (Synonyms: SHP625 chloride; LUM001 chloride; Lopixibat chloride)

Cat. No.: HY-16747 Purity: 99.08% ee.: 100.00%
COA Handling Instructions

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Maralixibat (SHP625) chloride is an orally active ileal bile acid transporter (IBAT) inhibitor. Maralixibat chloride can be used for the research of rare cholestatic liver diseases including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC) and biliary atresia.

For research use only. We do not sell to patients.

Maralixibat chloride Chemical Structure

Maralixibat chloride Chemical Structure

CAS No. : 228113-66-4

Size Price Stock Quantity
1 mg USD 390 In-stock
5 mg USD 980 In-stock
10 mg USD 1550 In-stock
25 mg USD 3100 In-stock
50 mg USD 4960 In-stock
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Based on 1 publication(s) in Google Scholar

Maralixibat chloride Related Antibodies

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Description

Maralixibat (SHP625) chloride is an orally active ileal bile acid transporter (IBAT) inhibitor. Maralixibat chloride can be used for the research of rare cholestatic liver diseases including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC) and biliary atresia[1][2].

In Vivo

Maralixibat chloride reduces elevations in sBA levels, improves liver function, and reduces liver tissue damage, in a rat partial bile duct ligation model of cholestasis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

710.41

Formula

C40H56ClN3O4S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=S1(CC(CCCC)(CCCC)[C@H](O)[C@H](C2=CC=C(OCC3=CC=C(C[N+]4(CC5)CCN5CC4)C=C3)C=C2)C6=CC(N(C)C)=CC=C61)=O.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (70.38 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4076 mL 7.0382 mL 14.0764 mL
5 mM 0.2815 mL 1.4076 mL 2.8153 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.08% ee.: 100.00%

COA (252 KB) HNMR (147 KB) NP-HPLC (299 KB) LCMS (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4076 mL 7.0382 mL 14.0764 mL 35.1909 mL
5 mM 0.2815 mL 1.4076 mL 2.8153 mL 7.0382 mL
10 mM 0.1408 mL 0.7038 mL 1.4076 mL 3.5191 mL
15 mM 0.0938 mL 0.4692 mL 0.9384 mL 2.3461 mL
20 mM 0.0704 mL 0.3519 mL 0.7038 mL 1.7595 mL
25 mM 0.0563 mL 0.2815 mL 0.5631 mL 1.4076 mL
30 mM 0.0469 mL 0.2346 mL 0.4692 mL 1.1730 mL
40 mM 0.0352 mL 0.1760 mL 0.3519 mL 0.8798 mL
50 mM 0.0282 mL 0.1408 mL 0.2815 mL 0.7038 mL
60 mM 0.0235 mL 0.1173 mL 0.2346 mL 0.5865 mL
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Maralixibat chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Maralixibat228113-66-4SHP625LUM001LopixibatSHP 625SHP-625LUM 001LUM-001Apical Sodium-Dependent Bile Acid TransporterASBTIleal Bile Acid TransporterIBATSLC10A2oralcholestatic liver diseasesInhibitorinhibitorinhibit

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