ASIP - agouti signaling protein Gene

Also Known as ASP; AGSW; AGTI; AGTIL; SHEP9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 434

About ASIP

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,186,493-34,269,344 (from NCBI)

This gene has 2 transcripts (splice variants), 163 orthologues, 1 paralogue and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]

ASIP Products (2)

mRNA Protein Name
NM_001385218.1 NP_001372147.1 agouti-signaling protein precursor
NM_001672.3 NP_001663.2 agouti-signaling protein precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
36536132 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASIP Protein Structure

Agouti

Agouti: Agouti protein (40 - 127)

  • 0
  • 100
  • 132 a.a.
Protein Preferred Names Protein Names

agouti-signaling protein

  • agouti signaling protein, nonagouti homolog

Related Diseases

Diseases Alias
Skin/Hair/Eye Pigmentation, Variation In, 9

  • SHEP9

  • Skin/Hair/Eye Pigmentation 9, Brown/Nonbrown Eyes

  • Skin/Hair/Eye Pigmentation 9, Red/Nonred Hair

  • Skin/Hair/Eye Pigmentation 9, Freckling/Sunburn

  • Skin/Hair/Eye Pigmentation 9, Dark/Light Hair

  • Pigmentation, Skin/Hair/Eye, Variation In, Type 9
Skin Carcinoma

  • Skin Cancer

  • Carcinoma Of Skin

  • Ca - Skin Cancer

  • Cancer Of Skin

  • Malignant Neoplasm Of Skin

  • Melanoma And Non-Melanoma Skin Cancer

  • Skin Cancers

  • Cancer, Skin
Albinism, Oculocutaneous, Type Ii

  • OCA2

  • Oculocutaneous Albinism Type 2

  • Oculocutaneous Albinism Type Ii

  • Albinoidism

  • Tyrosinase-Positive Oculocutaneous Albinism

  • Brown Oculocutaneous Albinism

  • Oculocutaneous Albinism, Tyrosinase-Positive

  • Albinism Ii

  • Albinism, Brown Oculocutaneous

  • Oculocutaneous Albinism, Type Ii, Modifier Of

  • Oculocutaneous Albinism, Type Ii

  • Albinism, Oculocutaneous, Type Ii, Modifier Of

  • Albinism 2

  • Albinism, Oculocutaneous, Type 2

  • Oculocutaneous Albinism Tyrosinase Positive

  • Oculocutaneous Albinism, Tyrosinase Positive

  • Albinism, Oculocutaneous, 2

  • Boca

  • Oca-2

  • Oculocutaneous Albinism Tyrosinase-Positive
Mongolian Spot

  • Mongolian Macula
Epithelial Recurrent Erosion Dystrophy

  • ERED

  • Corneal Erosions, Recurring Hereditary

  • Col17a1

  • Dystrophia Helsinglandica

  • Dystrophia Smolandiensis

  • Recurrent Hereditary Corneal Erosions

  • Rces

  • Recurrent Corneal Erosion Syndrome

  • Recurrent Erosion Of Cornea
Albinism, Oculocutaneous, Type Iii

  • Rufous Oculocutaneous Albinism

  • Oculocutaneous Albinism Type 3

  • OCA3

  • Roca

  • Xanthism

  • Oculocutaneous Albinism Type Iii

  • Albinism Iii

  • Oculocutaneous Albinism, Type Iii

  • Albinism 3

  • Albinism, Oculocutaneous, Type 3

  • Rufous Oca

  • Red Oculocutaneous Albinism

  • Xanthous Oculocutaneous Albinism

  • Albinism, Oculocutaneous, 3

  • Oca-Iii
Basal Cell Carcinoma

  • Basal Cell Cancer

  • Basal Cell Neoplasm

  • Basal Cell Carcinoma Of Skin

  • Malignant Basal Cell Tumor

  • Basal Cell Tumor

  • Epithelioma Basal Cell

  • Malignant Basal Cell Neoplasm

  • Rodent Ulcer

  • Carcinoma Basal Cell

  • Neoplasms, Basal Cell

  • Basal Cell Carcinomas

  • Experimental Organism Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Basalioma

  • Basal Cell Epithelioma Of Skin

  • Bcc - [Basal Cell Carcinoma] Of Skin

  • Rodent Ulcer Of Skin

  • Rodent Ulcer Of Unspecified Site

  • Basal Cell Epithelioma Of Unspecified Site
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Melanoma, Cutaneous Malignant 1

  • Familial Melanoma

  • Melanoma, Cutaneous Malignant, Susceptibility To, 1

  • Melanoma, Malignant

  • CMM1

  • Melanoma, Cutaneous Malignant

  • Cmm

  • Familial Atypical Mole-Malignant Melanoma Syndrome

  • Fammm

  • Melanoma, Familial

  • Mlm

  • Dysplastic Nevus Syndrome, Hereditary

  • Dns

  • B-K Mole Syndrome

  • Melanoma, Cutaneous Malignant, 1

  • Malignant Melanoma, Cutaneous

  • Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

  • Dysplastic Nevus Syndrome

  • Cutaneous Melanoma

  • Familial Atypical Mole Melanoma Syndrome

  • Hereditary Melanoma
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01094 ASIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10037 PARD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28629 Asip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ASIP VGNC VGNC:68345
Canis familiaris ASIP VGNC VGNC:38182
Mus musculus ASIP MGD MGI:87853
Bos taurus ASIP VGNC VGNC:26214
Rattus norvegicus ASIP RGD RGD:2003
Others ASIP NCBI