NOVA1 - NOVA alternative splicing regulator 1 Gene

Also Known as Nova-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4857

About NOVA1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:26,443,090-26,598,033 (from NCBI)

This gene has 13 transcripts (splice variants), 295 orthologues and 12 paralogues. Biased expression in brain (RPKM 10.5), fat (RPKM 4.3) and 12 other tissues.

Summary

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast Cancer, and small cell lung Cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

NOVA1 Products (12)

mRNA Protein Name
NM_001366390.2 NP_001353319.1 RNA-binding protein Nova-1 isoform 4
NM_001366391.2 NP_001353320.1 RNA-binding protein Nova-1 isoform 5
NM_001366392.2 NP_001353321.1 RNA-binding protein Nova-1 isoform 6
NM_001366393.2 NP_001353322.1 RNA-binding protein Nova-1 isoform 7
NM_001366394.2 NP_001353323.1 RNA-binding protein Nova-1 isoform 8
NM_001366395.2 NP_001353324.1 RNA-binding protein Nova-1 isoform 5
NM_001366396.2 NP_001353325.1 RNA-binding protein Nova-1 isoform 5
NM_001366397.2 NP_001353326.1 RNA-binding protein Nova-1 isoform 4
NM_001366398.2 NP_001353327.1 RNA-binding protein Nova-1 isoform 5
NM_002515.3 NP_002506.2 RNA-binding protein Nova-1 isoform 1
NM_006489.3 NP_006480.2 RNA-binding protein Nova-1 isoform 2
NM_006491.3 NP_006482.1 RNA-binding protein Nova-1 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27733149 GOA
enables sequence-specific mRNA binding IDA
IDA: Inferred from direct assay
10811881 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOVA1 Protein Structure

KH_1

KH_1: KH domain (53 - 111)

KH_1

KH_1: KH domain (174 - 237)

KH_1

KH_1: KH domain (424 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 507 a.a.
Protein Preferred Names Protein Names

RNA-binding protein Nova-1

  • neuro-oncological ventral antigen 1

NOVA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NOVA1 P51513 HTR6 Homo sapiens P50406
Y2H
30853821
Intra
NOVA1 P51513 HTR6 Homo sapiens P50406
Pull Down
30853821
Intra
NOVA1 P51513 HTR6 Homo sapiens P50406
Confocal
30853821
Intra
NOVA1 P51513 HTR6 Homo sapiens P50406
Anti Tag CoIP
30853821
Cross: Cross-species interaction Intra: Intraspecies interaction

NOVA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81676 Nova1 Antibody (YA1421) WB, IHC-P Human, Mouse, Rat
HY-P81676A Nova1 Antibody (YA1421)(PBS only) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Myoclonus
Cutaneous Adenocystic Carcinoma

  • Adenoid Cystic Eccrine Carcinoma

  • Adenoid Cystic Carcinoma Of The Skin

  • Adenoid Cystic Eccrine Carcinoma Of Skin
Partial Fetal Alcohol Syndrome
Oligodendroglioma

  • Oligodendroglial Neoplasm

  • Oligodendroglial Tumor

  • Oligodendroglial Tumors

  • Well Differentiated Oligodendroglioma
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09455 NOVA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NOVA1 RGD RGD:621345
Bos taurus NOVA1 VGNC VGNC:84869
Macaca mulatta NOVA1 VGNC VGNC:75373
Felis catus NOVA1 VGNC VGNC:68521
Canis familiaris NOVA1 VGNC VGNC:43902
Mus musculus NOVA1 MGD MGI:104297
Others NOVA1 NCBI