2. Gene
  3. IRAK4 - interleukin 1 receptor associated kinase 4 Gene

IRAK4 - interleukin 1 receptor associated kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 486601 | Gene type: protein coding

About IRAK4

Primary_assembly 27: 10,502,248-10,529,935 reverse strand.ROS_Cfam_1.0:CM025126.1

This gene has 2 transcripts (splice variants), 202 orthologues and 5 paralogues.

IRAK4 Products(9)

mRNA Protein Name
XM_038438434.1 XP_038294362.1 interleukin-1 receptor-associated kinase 4 isoform X1
XM_038438440.1 XP_038294368.1 interleukin-1 receptor-associated kinase 4 isoform X2
XM_038438432.1 XP_038294360.1 interleukin-1 receptor-associated kinase 4 isoform X1
XM_038438438.1 XP_038294366.1 interleukin-1 receptor-associated kinase 4 isoform X1
XM_038438433.1 XP_038294361.1 interleukin-1 receptor-associated kinase 4 isoform X1
XM_038438436.1 XP_038294364.1 interleukin-1 receptor-associated kinase 4 isoform X1
XM_038438435.1 XP_038294363.1 interleukin-1 receptor-associated kinase 4 isoform X1
XM_038438439.1 XP_038294367.1 interleukin-1 receptor-associated kinase 4 isoform X2
XM_038438437.1 XP_038294365.1 interleukin-1 receptor-associated kinase 4 isoform X1

IRAK4 Protein Structure

Death_IRAK4

Death_IRAK4: cd08793 (8 - 105)

STKc_IRAK4

STKc_IRAK4: cd14158 (169 - 456)

  • 0
  • 100
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  • 300
  • 400
  • 460 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 4

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-19836 Zimlovisertib Inhibitor 99.94% Phase 2
HY-135317 Emavusertib Inhibitor 99.97% Phase 2
HY-160487 KME-2780 Inhibitor 98.94% Phase 2
HY-109585 IRAK4-IN-7 Inhibitor 99.36% Phase 2
HY-135317B Emavusertib hydrochloride Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (69)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145483 KT-474 Inhibitor 99.77% Unkown
HY-18992 AS2444697 Inhibitor 99.54% Unkown
HY-139374 Zabedosertib Inhibitor 98.22% Unkown
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-153188 JNJ-1013 Degrader 99.97% Unkown
HY-111101 AZ1495 Inhibitor 98.07% Unkown
HY-114181 IRAK4-IN-4 Inhibitor 99.55% Unkown
HY-129966 PROTAC IRAK4 degrader-1 Degrader 99.77% Unkown
HY-148290 KTX-951 Degrader 99.60% Unkown
HY-159953 IRAK1/4/pan-FLT3 Kinase-IN-1 Inhibitor 99.25% Unkown
HY-135382A PROTAC IRAK4 degrader-3 Inhibitor 98.24% Unkown
HY-162359 BIO-7488 Inhibitor 99.44% Unkown
HY-175022 PROTAC IRAK4 degrader-13 Degrader 99.47% Unkown
HY-153224 GLPG2534 Inhibitor 98.73% Unkown
HY-175764 FIP22 Degrader 98.53% Unkown
HY-150735 IRAK4-IN-20 Inhibitor 97.04% Unkown
HY-179094 PSP-0119 Degrader 98.65% Unkown
HY-134911 HS-243 Inhibitor 99.95% Unkown
HY-146112 IRAK4-IN-14 Inhibitor 99.01% Unkown
HY-13276 IRAK inhibitor 2 Inhibitor 99.19% Unkown
HY-174455A APH02174 hemiformic Degrader / Unkown
HY-123854 PF-06426779 Inhibitor 99.89% Unkown
HY-77048 IRAK-4 protein kinase inhibitor 2 Inhibitor 98.07% Unkown
HY-174455 APH02174 Degrader / Unkown
HY-131903 HS271 Inhibitor 99.92% Unkown
HY-13278 IRAK inhibitor 4 Inhibitor 99.77% Unkown
HY-177515 IRAK4 modulator-2 Inhibitor 99.86% Unkown
HY-179095 UR241-2 Inhibitor 99.68% Unkown
HY-148238 GNE-2256 Inhibitor 99.14% Unkown
HY-13278A IRAK inhibitor 4 (trans) Inhibitor 99.02% Unkown
HY-143231 IRAK4-IN-8 Inhibitor / Unkown
HY-160654 IRAK4 modulator-1 Modulator 99.11% Unkown
HY-139317 PROTAC IRAK4 degrader-6 Inhibitor / Unkown
HY-178012 GLPG4471 Inhibitor / Unkown
HY-150733 IRAK4-IN-19 Inhibitor / Unkown
HY-150732 IRAK4-IN-18 Inhibitor / Unkown
HY-W900240 BMS-978299 Inhibitor / Unkown
HY-143486 IRAK4-IN-10 Inhibitor / Unkown
HY-183799 GSI526 Degrader / Unkown
HY-143485 IRAK4-IN-9 Inhibitor / Unkown
HY-146073 IRAK4-IN-12 Inhibitor / Unkown
HY-162641 AF-45 Inhibitor / Unkown
HY-146113 IRAK4-IN-15 Inhibitor / Unkown
HY-135382 PROTAC IRAK4 degrader-2 Inhibitor / Unkown
HY-168611 PROTAC IRAK4 ligand-4 Degrader / Unkown
HY-148275 KTX-955 Inhibitor / Unkown
HY-146072 IRAK4-IN-11 Inhibitor / Unkown
HY-181708 PROTAC IRAK4 degrader-14 Degrader / Unkown
HY-148276 KTX-497 / Unkown
HY-139316 PROTAC IRAK4 degrader-5 Inhibitor / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-176197 IRAK4-IN-31 Inhibitor / Unkown
HY-150594 IRAK4-IN-17 Inhibitor / Unkown
HY-123956 HG-12-6 Inhibitor / Unkown
HY-146111 IRAK4-IN-13 Inhibitor / Unkown
HY-172372 IRAK4-IN-30 Inhibitor / Unkown
HY-139315 PROTAC IRAK4 degrader-4 Inhibitor / Unkown
HY-158374 BIO-8169 Inhibitor / Unkown
HY-148277 KTX-612 / Unkown
HY-155574 IRAK4-IN-27 Inhibitor / Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-161620 DW18134 Inhibitor / Unkown
HY-149345 IRAK4-IN-24 Inhibitor / Unkown
HY-150593 IRAK4-IN-16 Inhibitor / Unkown
HY-174470 IRAK4 ligand-14 Ligand / Unkown
HY-168982 Lomonitinib Inhibitor / Unkown
HY-124995 BMS-986126 Inhibitor / Unkown
HY-180908 IRAK4-IN-34 Inhibitor / Unkown
HY-174843 IRAK4-IN-32 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens IRAK4 NCBI NCBI:51135
Mus musculus IRAK4 NCBI NCBI:266632