IRAK4 - interleukin 1 receptor associated kinase 4 Gene
Also Known as IPD1; IMD67; REN64; IRAK-4; NY-REN-64
Species: Homo sapiens
About IRAK4
This gene has 18 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 7.4), appendix (RPKM 6.9) and 25 other tissues.
Summary
This gene encodes a kinase that activates NF-kappaB in both the Toll-like Receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
IRAK4 Products (19)
| mRNA | Protein | Name |
|---|---|---|
| NM_001145258.2 | NP_001138730.1 | interleukin-1 receptor-associated kinase 4 isoform b |
| XM_005268943.4 | XP_005269000.1 | interleukin-1 receptor-associated kinase 4 isoform X1 |
| NM_016123.4 | NP_057207.2 | interleukin-1 receptor-associated kinase 4 isoform a |
| XM_017019390.3 | XP_016874879.1 | interleukin-1 receptor-associated kinase 4 isoform X1 |
| NM_001351342.2 | NP_001338271.1 | interleukin-1 receptor-associated kinase 4 isoform b |
| XM_006719438.4 | XP_006719501.1 | interleukin-1 receptor-associated kinase 4 isoform X1 |
| NM_001351344.2 | NP_001338273.1 | interleukin-1 receptor-associated kinase 4 isoform c |
| XM_005268945.5 | XP_005269002.1 | interleukin-1 receptor-associated kinase 4 isoform X1 |
| XM_011538431.3 | XP_011536733.1 | interleukin-1 receptor-associated kinase 4 isoform X1 |
| NM_001351338.2 | NP_001338267.1 | interleukin-1 receptor-associated kinase 4 isoform b |
| NM_001351343.2 | NP_001338272.1 | interleukin-1 receptor-associated kinase 4 isoform c |
| XM_005268944.5 | XP_005269001.1 | interleukin-1 receptor-associated kinase 4 isoform X1 |
| NM_001351341.2 | NP_001338270.1 | interleukin-1 receptor-associated kinase 4 isoform b |
| NM_001351339.2 | NP_001338268.1 | interleukin-1 receptor-associated kinase 4 isoform b |
| NM_001145256.2 | NP_001138728.1 | interleukin-1 receptor-associated kinase 4 isoform b |
| NM_001145257.2 | NP_001138729.1 | interleukin-1 receptor-associated kinase 4 isoform b |
| NM_001351345.2 | NP_001338274.1 | interleukin-1 receptor-associated kinase 4 isoform a |
| NM_001351340.2 | NP_001338269.1 | interleukin-1 receptor-associated kinase 4 isoform b |
| NM_001114182.3 | NP_001107654.1 | interleukin-1 receptor-associated kinase 4 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables kinase activity |
IDA
IDA: Inferred from direct assay
|
11960013 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12496252 | GOA |
| enables protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
33238146 | GOA |
| enables protein serine/threonine kinase activity |
EXP
EXP: Inferred from Experiment
|
11960013 | GOA |
| enables protein serine/threonine kinase activity |
IDA
IDA: Inferred from direct assay
|
11960013 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in interleukin-1-mediated signaling pathway |
IDA
IDA: Inferred from direct assay
|
20485341 | GOA |
| involved in interleukin-33-mediated signaling pathway |
IDA
IDA: Inferred from direct assay
|
11960013 | GOA |
| involved in neutrophil mediated immunity |
IMP
IMP: Inferred from mutant phenotype
|
19663824 | GOA |
| involved in neutrophil migration |
IMP
IMP: Inferred from mutant phenotype
|
19663824 | GOA |
| acts upstream of or within positive regulation of canonical NF-kappaB signal transduction |
IMP
IMP: Inferred from mutant phenotype
|
22158417 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in cell surface |
IDA
IDA: Inferred from direct assay
|
22851693 | GOA |
IRAK4 Protein Structure
Pkinase: Protein kinase domain (190 - 452)
- 0
- 100
- 200
- 300
- 400
- 460 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
interleukin-1 receptor-associated kinase 4 |
|
IRAK4 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
IRAK4 | Q9NWZ3 | MYD88 | Homo sapiens | Q99836-1 | 20485341 | |
|
Intra
|
IRAK4 | Q9NWZ3 | VSIG8 | Homo sapiens | P0DPA2 | 33961781 | |
|
Intra
|
IRAK4 | Q9NWZ3 | VSIG8 | Homo sapiens | P0DPA2 | 28514442 | |
|
Intra
|
IRAK4 | Q9NWZ3 | TRIM7 | Homo sapiens | Q9C029 | 32296183 | |
|
Intra
|
IRAK4 | Q9NWZ3 | TRIM7 | Homo sapiens | Q9C029 | 32296183 | |
|
Intra
|
IRAK4 | Q9NWZ3 | MYD88 | Homo sapiens | Q99836 | 31515488 | |
|
Intra
|
IRAK4 | Q9NWZ3 | MYD88 | Homo sapiens | Q99836 | 26871637 | |
|
Intra
|
IRAK4 | Q9NWZ3 | MYD88 | Homo sapiens | Q99836 | 26871637 | |
|
Intra
|
IRAK4 | Q9NWZ3 | MYD88 | Homo sapiens | Q99836 | 25502805 | |
|
Intra
|
IRAK4 | Q9NWZ3 | MYD88 | Homo sapiens | Q99836 | 26871637 | |
|
Intra
|
IRAK4 | Q9NWZ3 | IRAK2 | Homo sapiens | O43187 | 21903422 | |
|
Intra
|
IRAK4 | Q9NWZ3 | IRAK2 | Homo sapiens | O43187 | 20485341 | |
|
Intra
|
IRAK4 | Q9NWZ3 | PELI1 | Homo sapiens | Q96FA3 | 32296183 | |
|
Intra
|
IRAK4 | Q9NWZ3 | PELI1 | Homo sapiens | Q96FA3 | 32296183 | |
|
Intra
|
IRAK4 | Q9NWZ3 | PELI2 | Homo sapiens | Q9HAT8 | 12860405 | |
|
Intra
|
IRAK4 | Q9NWZ3 | IL36RN | Homo sapiens | Q9UBH0 | 32296183 | |
|
Intra
|
IRAK4 | Q9NWZ3 | IL36RN | Homo sapiens | Q9UBH0 | 32296183 | |
|
Intra
|
IRAK4 | Q9NWZ3 | IL36RN | Homo sapiens | Q9UBH0 | 32296183 | |
|
Cross
|
IRAK4 | Q9NWZ3 | Irak3 | Mus musculus | Q8K4B2 | 23376919 | |
|
Intra
|
IRAK4 | Q9NWZ3 | ZNF597 | Homo sapiens | Q96LX8 | 32296183 | |
|
Intra
|
IRAK4 | Q9NWZ3 | ZNF597 | Homo sapiens | Q96LX8 | 32296183 |
Recombinant IRAK4 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P73255 | IRAK4 Protein, Human (Active, sf9, His) | Q9NWZ3-1 (M1-S460) | ≥ 90%, as determined by reducing SDS-PAGE. |
IRAK4 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83370 | IRAK4 Antibody (YA3115) | WB, IHC-F, IHC-P, ICC/IF | Human |
| HY-P83370A | IRAK4 Antibody (YA3115)(PBS only) | WB, IHC-F, IHC-P, ICC/IF | Human |
| HY-P84834 | IRAK4 Antibody (YA4531) | WB, IHC-P, FC, ELISA | Human, Mouse, Rat, , Monkey |
| HY-P84834A | IRAK4 Antibody (YA4531)(PBS only) | WB, IHC-P, FC, ELISA | Human, Mouse, Rat, , Monkey |
| HY-P85231 | IRAK-4 Antibody (YA4923) | WB, IHC-P | Human, Mouse, Monkey |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Disease By Infectious Agent |
|
|
| Bacterial Infectious Disease |
|
|
| Immune Deficiency Disease |
|
|
| Lymphoplasmacytic Lymphoma |
|
|
| Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive |
|
|
| Ecthyma |
|
|
| Maxillary Sinusitis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Waldenstroem'S Macroglobulinemia |
|
|
| Chronic Maxillary Sinusitis |
|
|
| Chronic Mucocutaneous Candidiasis |
|
|
| Immunodeficiency 67 |
|
|
| Pericarditis |
|
|
| Smallpox |
|
|
| Glycogen Storage Disease Iv |
|
|
| Meningitis |
|
|
| Immunodeficiency 33 |
|
|
| Rheumatoid Arthritis |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | IRAK4 | VGNC | VGNC:42089 |
| Felis catus | IRAK4 | VGNC | VGNC:62972 |
| Macaca mulatta | IRAK4 | VGNC | VGNC:73617 |
| Rattus norvegicus | IRAK4 | RGD | RGD:1305303 |
| Bos taurus | IRAK4 | VGNC | VGNC:30268 |
| Mus musculus | IRAK4 | MGD | MGI:2182474 |
| Others | IRAK4 | NCBI |