Irak3 - interleukin-1 receptor-associated kinase 3 Gene

Also Known as IRAK-M; 4833428C18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 73914

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of macrophage tolerance induction; and response to molecule of Bacterial origin. Acts upstream of or within interleukin-1-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; and protein autophosphorylation. Located in cytoplasm and nucleus. Used to study osteoporosis and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Irak3 Products (2)

mRNA Protein Name
NM_001359184.1 NP_001346113.1 interleukin-1 receptor-associated kinase 3 isoform 2
NM_028679.4 NP_082955.2 interleukin-1 receptor-associated kinase 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
12054681 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
12054681 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
12054681 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12054681 MGI
Biological Process GO Annotation Evidence References Source
involved in cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
12054681 MGI
acts upstream of or within interleukin-1-mediated signaling pathway IDA
IDA: Inferred from direct assay
12054681 MGI
involved in negative regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
17379480 MGI
involved in negative regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
12150927 MGI
involved in negative regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
12150927 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
12150927 MGI
involved in negative regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
12150927 MGI
involved in negative regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
17379480 MGI
involved in negative regulation of toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12150927 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
12150927 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
12054681 MGI
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
29686383 MGI
involved in positive regulation of macrophage tolerance induction IMP
IMP: Inferred from mutant phenotype
12150927 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
12054681 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12054681 MGI
involved in regulation of protein-containing complex disassembly IDA
IDA: Inferred from direct assay
12054681 MGI
involved in response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
12150927 MGI
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
12150927 MGI
involved in response to peptidoglycan IMP
IMP: Inferred from mutant phenotype
12150927 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17379480 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17379480 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 3

  • IL-1 receptor-associated kinase M

  • inactive IL-1 receptor-associated kinase 3

Irak3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Irak3 Q8K4B2 Irak4 Mus musculus Q8R4K2
Anti Bait CoIP
23376919
Intra
Irak3 Q8K4B2 Traf6 Mus musculus P70196
Anti Tag CoIP
23376919
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181899 IRAK3 ligand-3 Ligand / Unkown
HY-181898 PROTAC IRAK3 degrader-2 Degrader / Unkown
HY-142662 PROTAC IRAK3 degrader-1 Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irak3 NCBI NCBI:11213