KTX-612
KTX-612 is an orally active IRAK4 PROTAC degrader with a DC50 value of 7 nM. KTX-612 can be used for the research of oncology.
(Pink: IRAK4 ligand (HY-150735); Blue: Cereblon ligand (HY-10984); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2573298-14-1
- Formula: C46H51F3N8O6
- Molecular Weight:868.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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IRAK4 7 nM (DC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| OCI-Ly10 | IC50 |
8 nM
Compound: 24
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Antiproliferative activity against human OCI-Ly10 cells measured after 4 days by CellTiter-Glo Luminescent Cell Viability Assay
Antiproliferative activity against human OCI-Ly10 cells measured after 4 days by CellTiter-Glo Luminescent Cell Viability Assay
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[PMID: 38920289] |
Chemical Information
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CAS No. 2573298-14-1
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Molecular Weight 868.94
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Formula C46H51F3N8O6
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SMILES
CC(C)(O)C1=CC2=NN(C=C2C=C1NC(C3=CC=CC(C(F)(F)F)=N3)=O)[C@H](CC4)CC[C@@H]4CN(CC5)CCC5(C6)CC6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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