IRAK4-IN-20
Based on 1 Customer Validation
IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 can be used for acute respiratory distress syndrome (ARDS) research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 97.04%
- No. CAS: 1931994-80-7
- Fòrmula: C22H25F3N4O3
- Peso molecular:450.45
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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IRAK-4 protein kinase inhibitor 2IRAK-4 Inhibitor
Actividad biológica
Descripciòn
IC50 & Target
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IRAK4 3.55 nM (IC50) |
In Vitro
IRAK4-IN-20 (Compound BAY-1834845) (500 nM, 20 h) decreases inflammatory cytokines secretion effectively in an in vitro treatment of LPS stimulated human peripheral blood mononuclear cells (PBMC)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Balb/c mice (aged 6–7 weeks), LPS-induced ARDS mouse model[1]
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Dosage:150 mg/kg
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Administration:Oral administration, 30 min before LPS modeling or twice 4 h and 12 h after LPS modeling
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Result:Remarkably decreased inflammatory cells infiltrating lung tissue and neutrophil count in BALF.
Effectively reduced the numbers of total T cells, monocyte, and macrophages.
Largely preserved the signatures of naïve lymphocytes and stromal cells such as endothelial cells, chondrocytes, and smooth muscle cells.
Regulated inflammation and innate immunity genes more efficiently than Dexamethasone (HY-14648).
Chemical Information
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No. CAS 1931994-80-7
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Appearance Solid
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Peso molecular 450.45
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Fòrmula C22H25F3N4O3
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Color White to light yellow
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SMILES
O=C(C1=NC(C(F)(F)F)=CC=C1)NC2=CC3=CN(CCC(C)(O)C)N=C3C=C2C(C)(O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (277.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2200 mL | 11.1000 mL | 22.2000 mL | 55.5001 mL |
| 5 mM | 0.4440 mL | 2.2200 mL | 4.4400 mL | 11.1000 mL | |
| 10 mM | 0.2220 mL | 1.1100 mL | 2.2200 mL | 5.5500 mL | |
| 15 mM | 0.1480 mL | 0.7400 mL | 1.4800 mL | 3.7000 mL | |
| 20 mM | 0.1110 mL | 0.5550 mL | 1.1100 mL | 2.7750 mL | |
| 25 mM | 0.0888 mL | 0.4440 mL | 0.8880 mL | 2.2200 mL | |
| 30 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8500 mL | |
| 40 mM | 0.0555 mL | 0.2775 mL | 0.5550 mL | 1.3875 mL | |
| 50 mM | 0.0444 mL | 0.2220 mL | 0.4440 mL | 1.1100 mL | |
| 60 mM | 0.0370 mL | 0.1850 mL | 0.3700 mL | 0.9250 mL | |
| 80 mM | 0.0278 mL | 0.1388 mL | 0.2775 mL | 0.6938 mL | |
| 100 mM | 0.0222 mL | 0.1110 mL | 0.2220 mL | 0.5550 mL |
IRAK4-IN-20 Related Classifications
HY-150735 Related Classifications
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