2. Immunology/Inflammation
  3. IRAK
  4. IRAK4-IN-20

IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 can be used for acute respiratory distress syndrome (ARDS) research.

For research use only. We do not sell to patients.

IRAK4-IN-20 Chemical Structure

IRAK4-IN-20 Chemical Structure

CAS No. : 1931994-80-7

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Based on 1 publication(s) in Google Scholar

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Description

IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 can be used for acute respiratory distress syndrome (ARDS) research[1].

IC50 & Target

IRAK4

3.55 nM (IC50)

In Vitro

IRAK4-IN-20 (Compound BAY-1834845) (500 nM, 20 h) decreases inflammatory cytokines secretion effectively in an in vitro treatment of LPS stimulated human peripheral blood mononuclear cells (PBMC)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IRAK4-IN-20 Related Antibodies
In Vivo

IRAK4-IN-20 (Compound BAY-1834845) (150 mg/kg; p.o.; once or twice) effectively prevents acute respiratory distress syndrome in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c mice (aged 6–7 weeks), LPS-induced ARDS mouse model[1]
Dosage: 150 mg/kg
Administration: Oral administration, 30 min before LPS modeling or twice 4 h and 12 h after LPS modeling
Result: Remarkably decreased inflammatory cells infiltrating lung tissue and neutrophil count in BALF.
Effectively reduced the numbers of total T cells, monocyte, and macrophages.
Largely preserved the signatures of naïve lymphocytes and stromal cells such as endothelial cells, chondrocytes, and smooth muscle cells.
Regulated inflammation and innate immunity genes more efficiently than Dexamethasone (HY-14648).
Molecular Weight

450.45

Formula

C22H25F3N4O3
CAS No.
SMILES

O=C(C1=NC(C(F)(F)F)=CC=C1)NC2=CC3=CN(CCC(C)(O)C)N=C3C=C2C(C)(O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IRAK4-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-201931994-80-7IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseacute respiratory distress syndromeARDSInhibitorinhibitorinhibit

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