IRAK4-IN-34
IRAK4-IN-34 (compound 19) is a potent, selective, and orally active Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 of 0.73 nM. IRAK4-IN-34 exhibits good selectivity vs both hERG and other kinases. IRAK4-IN-34 shows favorable in vivo PK properties. IRAK4-IN-34 can be used for inflammatory diseases research.
For research use only. We do not sell to patients.
- CAS No.: 2411498-83-2
- Formula: C28H29N9O2S
- Molecular Weight:555.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IRAK4 0.73 nM (IC50) |
Chemical Information
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CAS No. 2411498-83-2
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Molecular Weight 555.65
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Formula C28H29N9O2S
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SMILES
N#CC1=CC2=CC=C(C3=NC=C(C(NC4(COC4)C)=C3)C5=NN=C(S5)N6C[C@@H]7CC[C@H](C6)[C@H]7NC(C)=O)N2N=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IRAK4-IN-34 Related Classifications
HY-180908 Related Classifications
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