2411498-83-2
2411498-83-2
Chemical Structure
IRAK4-IN-34
- CAS No.: 2411498-83-2
- Formula:C28H29N9O2S
- Molecular Weight:555.65
InChIKey: IUEZGLVIWNJLTB-HBNMSFMJSA-N
SMILES: N#CC1=CC2=CC=C(C3=NC=C(C(NC4(COC4)C)=C3)C5=NN=C(S5)N6C[C@@H]7CC[C@H](C6)[C@H]7NC(C)=O)N2N=C1
Biological Activity: IRAK4-IN-34 (compound 19) is a potent, selective, and orally active Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 of 0.73 nM. IRAK4-IN-34 exhibits good selectivity vs both hERG and other kinases. IRAK4-IN-34 shows favorable in vivo PK properties. IRAK4-IN-34 can be used for inflammatory diseases research[1].
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IRAK4-IN-34 | IRAK4-IN-34 (compound 19) is a potent, selective, and orally active Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 of 0.73 nM. IRAK4-IN-34 exhibits good selectivity vs both hERG and other kinases. IRAK4-IN-34 shows favorable in vivo PK properties. IRAK4-IN-34 can be used for inflammatory diseases research. | |||||||||||||||||||||
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References
Keywords
