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Cat. No.: HY-122707

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IRAK4-IN-5

IRAK4-IN-5 is an interleukin-1 receptor-associated kinase 4 (IRAK-4) inhibitor with a K_i value of 2.8 nM. IRAK4-IN-5 interacts with non-conserved residues of IRAK-4, thereby conferring selectivity over related kinases. IRAK4-IN-5 can be used in the research of inflammatory lesions (atherosclerosis, arthritis).

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CAS No.: 509093-72-5
화학식: C₂₇H₂₅F₃N₄O
분자량:478.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

IRAK4-IN-5 Chemical Structure

CAS No.: 509093-72-5

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

IRAK4

2.8 nM (Ki)

All IRAK Isoforms :

All Interleukin Related Isoforms :

In Vitro

Innate ImmunityCytokines & ChemokinesOthers

Innate Immunity

Cytokines & Chemokines

IRAK4-IN-5 (compound 16) inhibits IL-1-induced NF-κB activation in primary human monocytes with an IC₅₀ of 0.3 μM^[1].

Others

IRAK4-IN-5 potently binds purified IRAK-4 with a K_i of 2.8 nM, and exhibits 217-fold selectivity over IRAK-1 and 892-fold selectivity over TAK1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Parmacokinetics

Species	Dose	Route	CL	T_1/2	AUC_0-∞
Rat^[1]	0.5 mg/kg	i.v.	0.54 L/h/kg	23.7 h	1023 μM·h

Chemical Information

CAS No. 509093-72-5
분자량 478.51
화학식 C₂₇H₂₅F₃N₄O
SMILES

O=C(C1=CC=CC(C(F)(F)F)=C1)NC2=NC3=C(N2C4=CC=CC=C4)C=CC(CN5CCCCC5)=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang Z, et al. Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5546-50.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

IRAK4-IN-5

All IRAK Isoforms

All Interleukin Related Isoforms