1. Immunology/Inflammation NF-κB
  2. IRAK NF-κB
  3. IRAK4-IN-17

IRAK4-IN-17 (Compound 5) is a potent IRAK4 inhibitor with the IC50 of 1.3 nM. IRAK4-IN-17 can be used in large B-cell lymphoma (DLBCL) research.

For research use only. We do not sell to patients.

IRAK4-IN-17 Chemical Structure

IRAK4-IN-17 Chemical Structure

CAS No. : 2183503-33-3

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Description

IRAK4-IN-17 (Compound 5) is a potent IRAK4 inhibitor with the IC50 of 1.3 nM[1]. IRAK4-IN-17 can be used in large B-cell lymphoma (DLBCL) research[1].

IC50 & Target[1]

IRAK4

1.3 nM (IC50)

In Vitro

IRAK4-IN-17 (0.7-40.1 μM; 72 h) selectively suppresses OCI-LY10 and TMD8 cells with MYD88 L265P mutation[1].
IRAK4-IN-17 (0.3-10 μM; 2 h) inhibits the viability of DLBCL cells by targeting IRAK4 signaling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: OCI-LY10, TMD8, Ramos and HT cells
Concentration: 0.7-40.1 μM
Incubation Time: 72 hours
Result: Suppressed OCI-LY10 and TMD8 cells with MYD88 L265P mutation (IC50=0.7 μM and 1.2 μM, respectively), but not Ramos and HT cell lines with WT MYD88 (IC50=11.4 μM and 40.1 μM, respectively).

Western Blot Analysis[1]

Cell Line: OCI-LY10 and TMD8 cells
Concentration: 0.3, 1, 3 and 10 μM
Incubation Time: 2 hours
Result: Inhibited the phosphorylation of IRAK4 and the downstream molecules, IKKβ and NF-κB transcription factor (p65) in OCI-LY10 and TMD8 cells.
Molecular Weight

390.39

Formula

C17H20F2N8O

CAS No.
SMILES

O=C(C1=CN=C2C=CC(N[C@H]3CNCCC3)=NN21)NC4=CN(C)N=C4C(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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IRAK4-IN-17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
IRAK4-IN-17
Cat. No.:
HY-150594
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