2. Immunology/Inflammation
  3. IRAK
  4. KTX-497

KTX-497 is an IRAK4 degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology.

For research use only. We do not sell to patients.

KTX-497 Chemical Structure

KTX-497 Chemical Structure

CAS No. : 2432993-46-7

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KTX-497 Related Antibodies

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IRAK1 IRAK4

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Description

KTX-497 is an IRAK4 degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1].

IC50 & Target

IRAK4

3 nM (DC50)

In Vitro

KTX-497 has activity for IRAK4 with a DC50 value of 3 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KTX-497 Related Antibodies
In Vivo

KTX-497 (oral; 10 mg/kg) impacts oral absorption[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 10 mg/kg
Administration: Oral
Result: Impacted oral absorption.
Molecular Weight

854.92

Formula

C45H49F3N8O6
CAS No.
SMILES

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(NC4CC5(CCN(CC5)C[C@@H]6CC[C@@H](N7C=C8C(C=C(C(NC(C9=CC=CC(C(F)(F)F)=N9)=O)=C8)C(C)(O)C)=N7)CC6)C4)=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KTX-497 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KTX-4972432993-46-7KTX497KTX 497IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseIRAK4degraderactive compoundoncologyInhibitorinhibitorinhibit

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KTX-497
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HY-148276
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