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PFDN5 - prefoldin subunit 5 Gene

Also Known as MM1; MM-1; PFD5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5204

About PFDN5

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,295,542-53,299,450 (from NCBI)

This gene has 27 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in ovary (RPKM 223.5), thyroid (RPKM 192.0) and 25 other tissues.

Summary

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

PFDN5 Products (2)

mRNA	Protein	Name
NM_002624.4	NP_002615.2	prefoldin subunit 5 isoform alpha
NM_145897.3	NP_665904.1	prefoldin subunit 5 isoform gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	23614719	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17728244	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	30955883	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18281035	GOA
involved in negative regulation of amyloid fibril formation	IDA IDA: Inferred from direct assay	23614719	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18281035	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	30955883	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of prefoldin complex	IDA IDA: Inferred from direct assay	23614719	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PFDN5 Protein Structure

Prefoldin

0
100
154 a.a.

Protein Preferred Names	Protein Names
prefoldin subunit 5	c-myc binding protein

PFDN5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PFDN5	Q99471	GSTO2	Homo sapiens	Q9H4Y5	Validated Y2H	32296183
Intra	PFDN5	Q99471	DOK5	Homo sapiens	Q9P104-2	Validated Y2H	32296183
Intra	PFDN5	Q99471	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
Intra	PFDN5	Q99471	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PFDN5	Q99471	ZNF148	Homo sapiens	Q9UQR1-2	Validated Y2H	32296183
Intra	PFDN5	Q99471	HAPLN2	Homo sapiens	Q9GZV7	Validated Y2H	32296183
Intra	PFDN5	Q99471	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	PFDN5	Q99471	VGLL1	Homo sapiens	Q99990	Validated Y2H	32296183
Intra	PFDN5	Q99471	VGLL1	Homo sapiens	Q99990	Y2H Array	32296183
Intra	PFDN5	Q99471	VGLL1	Homo sapiens	Q99990	Y2H Prey Pooling	32296183
Intra	PFDN5	Q99471	VAX2	Homo sapiens	Q9UIW0	Validated Y2H	32296183
Intra	PFDN5	Q99471	PITX2	Homo sapiens	Q99697-2	Validated Y2H	32296183
Intra	PFDN5	Q99471	CIMIP1	Homo sapiens	Q9H1P6	Validated Y2H	32296183
Intra	PFDN5	Q99471	IRX2	Homo sapiens	Q9BZI1	Validated Y2H	32296183
Intra	PFDN5	Q99471	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
Intra	PFDN5	Q99471	PHF24	Homo sapiens	Q9UPV7	Validated Y2H	32296183
Intra	PFDN5	Q99471	MRPL45	Homo sapiens	Q9BRJ2	Validated Y2H	32296183
Intra	PFDN5	Q99471	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	PFDN5	Q99471	SMG9	Homo sapiens	Q9H0W8	Validated Y2H	32296183
Intra	PFDN5	Q99471	MYOT	Homo sapiens	Q9UBF9	Validated Y2H	32296183
Intra	PFDN5	Q99471	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	32296183
Intra	PFDN5	Q99471	PSME3	Homo sapiens	P61289	Y2H Array	25416956
Intra	PFDN5	Q99471	PSME3	Homo sapiens	P61289	Y2H Array	32296183
Intra	PFDN5	Q99471	GNB1	Homo sapiens	P62873	Lumier	25036637
Intra	PFDN5	Q99471	VBP1	Homo sapiens	P61758	Y2H Prey Pooling	32296183
Intra	PFDN5	Q99471	VBP1	Homo sapiens	P61758	Y2H Array	32296183
Intra	PFDN5	Q99471	PFDN2	Homo sapiens	Q9UHV9	Validated Y2H	32296183
Intra	PFDN5	Q99471	GLRX3	Homo sapiens	O76003	Validated Y2H	25416956
Intra	PFDN5	Q99471	PSMB4	Homo sapiens	P28070	Y2H Array	32296183
Intra	PFDN5	Q99471	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	PFDN5	Q99471	BHLHE40	Homo sapiens	O14503	Y2H Array	32296183
Intra	PFDN5	Q99471	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	32296183
Intra	PFDN5	Q99471	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	PFDN5	Q99471	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	PFDN5	Q99471	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	PFDN5	Q99471	KLHL42	Homo sapiens	Q9P2K6	Validated Y2H	32296183
Intra	PFDN5	Q99471	TCF19	Homo sapiens	Q9Y242	Validated Y2H	32296183
Intra	PFDN5	Q99471	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	PFDN5	Q99471	TAF6L	Homo sapiens	Q9Y6J9	Validated Y2H	32296183
Intra	PFDN5	Q99471	C10orf62	Homo sapiens	Q5T681	Y2H Array	32296183
Intra	PFDN5	Q99471	C10orf62	Homo sapiens	Q5T681	Y2H Prey Pooling	32296183
Intra	PFDN5	Q99471	MYOZ1	Homo sapiens	Q9NP98	Validated Y2H	32296183
Intra	PFDN5	Q99471	SYT17	Homo sapiens	Q9BSW7	Y2H Prey Pooling	32296183
Intra	PFDN5	Q99471	SYT17	Homo sapiens	Q9BSW7	Validated Y2H	32296183
Intra	PFDN5	Q99471	SYT17	Homo sapiens	Q9BSW7	Y2H Array	32296183
Intra	PFDN5	Q99471	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	31515488
Intra	PFDN5	Q99471	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25416956
Intra	PFDN5	Q99471	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	PFDN5	Q99471	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	PFDN5	Q99471	NEUROG2	Homo sapiens	Q9H2A3	Y2H Prey Pooling	32296183
Intra	PFDN5	Q99471	NEUROG2	Homo sapiens	Q9H2A3	Validated Y2H	32296183
Intra	PFDN5	Q99471	NEUROG2	Homo sapiens	Q9H2A3	Y2H Array	32296183
Intra	PFDN5	Q99471	SNRNP25	Homo sapiens	Q9BV90	Validated Y2H	32296183
Intra	PFDN5	Q99471	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183
Cross	PFDN5	Q99471	vIRF-3	Human herpesvirus 8	Q9DUN1	Anti Tag CoIP	17728244
Cross	PFDN5	Q99471	vIRF-3	Human herpesvirus 8	Q9DUN1	Pull Down	17728244
Cross	PFDN5	Q99471	vIRF-3	Human herpesvirus 8	Q9DUN1	Y2H	17728244
Cross	PFDN5	Q99471	vIRF-3	Human herpesvirus 8	Q9DUN1	Anti Bait CoIP	17728244

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PFDN5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76542	PFDN5 Protein, Human (His)	Q99471 (M1-A154)	≥ 90%, as determined by reducing SDS-PAGE.

PFDN5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81972	PFDN5 Antibody (YA1717)	WB, IHC-P, IP	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10359	PFDN5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20080	Pfdn5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26583	Pfdn5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PFDN5	RGD	RGD:1311436
Bos taurus	PFDN5	VGNC	VGNC:32767
Canis familiaris	PFDN5	VGNC	VGNC:97212
Mus musculus	PFDN5	MGD	MGI:1928753
Macaca mulatta	PFDN5	VGNC	VGNC:100086
Others	PFDN5	NCBI