GSTO2 - glutathione S-transferase omega 2 Gene

Also Known as GSTO 2-2; bA127L20.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 119391

About GSTO2

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:104,269,184-104,304,950 (from NCBI)

This gene has 7 transcripts (splice variants), 542 orthologues and 14 paralogues. Broad expression in skin (RPKM 2.1), testis (RPKM 1.8) and 21 other tissues.

Summary

The protein encoded by this gene is an omega class Glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

GSTO2 Products (4)

mRNA Protein Name
NM_001191013.2 NP_001177942.1 glutathione S-transferase omega-2 isoform 2
NM_001191014.2 NP_001177943.1 glutathione S-transferase omega-2 isoform 3
NM_001191015.2 NP_001177944.1 glutathione S-transferase omega-2 isoform 4
NM_183239.2 NP_899062.1 glutathione S-transferase omega-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables glutathione dehydrogenase (ascorbate) activity IDA
IDA: Inferred from direct assay
15970797 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables oxidoreductase activity IDA
IDA: Inferred from direct assay
15970797 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in L-ascorbic acid metabolic process IDA
IDA: Inferred from direct assay
15970797 GOA
involved in cellular response to arsenic-containing substance IDA
IDA: Inferred from direct assay
15970797 GOA
involved in xenobiotic metabolic process IDA
IDA: Inferred from direct assay
15970797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTO2 Protein Structure

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (27 - 100)

GST_C_2

GST_C_2: Glutathione S-transferase, C-terminal domain (143 - 204)

  • 0
  • 100
  • 200
  • 243 a.a.
Protein Preferred Names Protein Names

glutathione S-transferase omega-2

  • GSTO-2

GSTO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GSTO2 Q9H4Y5 GSTO2 Homo sapiens Q9H4Y5
Validated Y2H
32296183
Intra
GSTO2 Q9H4Y5 GSTO2 Homo sapiens Q9H4Y5
Y2H Array
25416956
Intra
GSTO2 Q9H4Y5 GSTO2 Homo sapiens Q9H4Y5
Y2H Array
32296183
Intra
GSTO2 Q9H4Y5 MUM1 Homo sapiens Q9H6H2
Validated Y2H
25416956
Intra
GSTO2 Q9H4Y5 GSTO2 Homo sapiens Q9H4Y5
Y2H Prey Pooling
32296183
Intra
GSTO2 Q9H4Y5 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
GSTO2 Q9H4Y5 TFAP2A Homo sapiens P05549
Y2H Prey Pooling
25416956
Intra
GSTO2 Q9H4Y5 TFAP2A Homo sapiens P05549
Y2H Array
25416956
Intra
GSTO2 Q9H4Y5 MUM1 Homo sapiens Q9H6H2
Y2H Prey Pooling
25416956
Intra
GSTO2 Q9H4Y5 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
GSTO2 Q9H4Y5 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
GSTO2 Q9H4Y5 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chronic Closed-Angle Glaucoma

  • Anatomical Narrow Angle Glaucoma

  • Chronic Angle-Closure Glaucoma

  • Chronic Narrow Angle Glaucoma

  • Secondary Angle-Closure Glaucoma - Synechial
Cataract

  • Cataracts

  • Cat - [Cataract]

  • Cataract Form

  • Lens Opacity

  • Lens Opacities
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178372 GSTO1-IN-4 Inhibitor / Unkown
HY-RS05885 GSTO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W615446 GSTO1-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GSTO2 VGNC VGNC:110343
Mus musculus GSTO2 MGD MGI:1915464
Macaca mulatta GSTO2 VGNC VGNC:106055
Bos taurus GSTO2 VGNC VGNC:29687
Felis catus GSTO2 VGNC VGNC:62732
Rattus norvegicus GSTO2 RGD RGD:1310764
Others GSTO2 NCBI