GPR88 - G protein-coupled receptor 88 Gene

Also Known as STRG; COCPMR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54112

About GPR88

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:100,538,139-100,542,021 (from NCBI)

This gene has 1 transcript (splice variant), 147 orthologues, 33 paralogues and is associated with 1 phenotype. Biased expression in spleen (RPKM 5.3), liver (RPKM 2.4) and 4 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]

GPR88 Products (1)

mRNA Protein Name
NM_022049.3 NP_071332.2 probable G-protein coupled receptor 88

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta2-adrenergic receptor activity IDA
IDA: Inferred from direct assay
23936473 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
35501348 GOA
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
23936473 GOA
Cellular Component GO Annotation Evidence References Source
located in ciliary membrane IDA
IDA: Inferred from direct assay
23936473 GOA
located in cilium IDA
IDA: Inferred from direct assay
28154160 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR88 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (49 - 336)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 88

  • striatum-specific G-protein coupled receptor

Related Diseases

Diseases Alias
Choreatic Disease

  • Chorea

  • Hereditary Chorea
Chorea, Childhood-Onset, With Psychomotor Retardation

  • COCPMR

  • Chorea
Pituitary Adenoma 2, Growth Hormone-Secreting

  • PITA2

  • Acromegaly Due To Pituitary Adenoma 2

  • Acromegaly, X-Linked

  • Growth Hormone Secreting Pituitary Adenoma 2

  • Pituitary Adenoma, Growth Hormone-Secreting, 2

  • Pituitary Adenoma 2, Gh-Secreting

  • Gh-Secreting Pituitary Adenoma 2

  • X-Linked Acromegaly

  • Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
Dyskinetic Cerebral Palsy

  • Athetoid Cerebral Palsy

  • Athetoid Dyskinetic Cerebral Palsy

  • Cerebral Palsy Athetoid

  • Cerebral Palsy Dyskinetic

  • Athetoid Cerebral Paralysis

  • Dyskinetic Cerebral Paralysis

  • Vogt Disease

  • Athetoid Cerebrum Palsy

  • Double Athetosis Syndrome

  • État Marbré
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112612A RTI-13951-33 hydrochloride 98.56% Unkown
HY-100013A1 (1R,2R)-2-PCCA hydrochloride 98.08% Unkown
HY-100013C 2-PCCA hydrochloride 99.61% Unkown
HY-167856A RTI-122 dihydrochloride Agonist 99.36% Unkown
HY-156771 GPR88-IN-1 Inhibitor 99.17% Unkown
HY-112612 RTI-13951-33 / Unkown
HY-167856 RTI-122 Agonist / Unkown
HY-156772 GPR88 agonist 2 Agonist 99.57% Unkown
HY-100013 2-PCCA Agonist / Unkown
HY-100013B1 (1S,2S)-2-PCCA hydrochloride Control 99.65% Unkown
HY-162660 BI-9508 Agonist / Unkown
HY-163096 GPR88 agonist 3 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GPR88 MGD MGI:1927653
Canis familiaris GPR88 VGNC VGNC:54029
Rattus norvegicus GPR88 RGD RGD:61921
Bos taurus GPR88 VGNC VGNC:29604
Others GPR88 NCBI