ARHGEF10L - Rho guanine nucleotide exchange factor 10 like Gene

Also Known as GrinchGEF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55160

About ARHGEF10L

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,513,435-17,697,875 (from NCBI)

This gene has 9 transcripts (splice variants), 256 orthologues, 2 paralogues and is associated with 76 phenotypes. Ubiquitous expression in kidney (RPKM 7.7), colon (RPKM 6.9) and 24 other tissues.

Summary

This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]

ARHGEF10L Products (5)

mRNA Protein Name
NM_001011722.2 NP_001011722.2 rho guanine nucleotide exchange factor 10-like protein isoform 2
NM_001319837.1 NP_001306766.1 rho guanine nucleotide exchange factor 10-like protein isoform 3
NM_001319838.1 NP_001306767.1 rho guanine nucleotide exchange factor 10-like protein isoform 4
NM_001328124.1 NP_001315053.1 rho guanine nucleotide exchange factor 10-like protein isoform 5
NM_018125.4 NP_060595.3 rho guanine nucleotide exchange factor 10-like protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
16112081 GOA
Biological Process GO Annotation Evidence References Source
involved in SREBP signaling pathway IDA
IDA: Inferred from direct assay
16112081 GOA
involved in positive regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
16112081 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
16112081 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF10L Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (323 - 502)

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  • 1279 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 10-like protein

  • Rho guanine nucleotide exchange factor (GEF) 10-like

Related Diseases

Diseases Alias
Post-Vaccinal Encephalitis

  • Encephalitis Following Immunization Procedures

  • Postvaccinal Encephalomyelitis

  • Encephalomyelitis, Acute Disseminated
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00947 ARHGEF10L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARHGEF10L VGNC VGNC:38073
Macaca mulatta ARHGEF10L VGNC VGNC:69908
Bos taurus ARHGEF10L VGNC VGNC:26105
Rattus norvegicus ARHGEF10L RGD RGD:1585585
Felis catus ARHGEF10L VGNC VGNC:59897
Mus musculus ARHGEF10L MGD MGI:1920004
Others ARHGEF10L NCBI