DNMT1 - DNA methyltransferase 1 Gene

Species: Macaca mulatta

Gene Type: protein coding
Gene ID: 574321

About DNMT1

Primary_assembly 19: 9,879,883-9,942,600 reverse strand.Mmul_10:CM014354.1

This gene has 2 transcripts (splice variants), 215 orthologues and 1 paralogue.

DNMT1 Products (9)

mRNA Protein Name
XM_028839275.1 XP_028695108.1 DNA (cytosine-5)-methyltransferase 1 isoform X2
XM_015122839.2 XP_014978325.2 DNA (cytosine-5)-methyltransferase 1 isoform X1
XM_028839277.1 XP_028695110.1 DNA (cytosine-5)-methyltransferase 1 isoform X1
XM_015122837.2 XP_014978323.2 DNA (cytosine-5)-methyltransferase 1 isoform X1
XM_015122836.2 XP_014978322.2 DNA (cytosine-5)-methyltransferase 1 isoform X5
XM_015122838.2 XP_014978324.2 DNA (cytosine-5)-methyltransferase 1 isoform X6
XM_028839276.1 XP_028695109.1 DNA (cytosine-5)-methyltransferase 1 isoform X3
XM_015122835.2 XP_014978321.2 DNA (cytosine-5)-methyltransferase 1 isoform X4
XM_028839278.1 XP_028695111.1 DNA (cytosine-5)-methyltransferase 1 isoform X7

DNMT1 Protein Structure

DMAP_binding

DMAP_binding: pfam06464 (167 - 244)

DNMT1-RFD

DNMT1-RFD: pfam12047 (504 - 639)

zf-CXXC

zf-CXXC: pfam02008 (750 - 796)

BAH_Dnmt1_I

BAH_Dnmt1_I: cd04760 (859 - 982)

BAH_Dnmt1_II

BAH_Dnmt1_II: cd04711 (1070 - 1206)

Dcm

Dcm: COG0270 (1243 - 1700)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1725 a.a.
Protein Preferred Names Protein Names

DNA (cytosine-5)-methyltransferase 1

  • DNA (cytosine-5-)-methyltransferase 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0004 Decitabine Inhibitor 99.97% Yes
HY-10586 5-Azacytidine Inhibitor 99.91% Yes
HY-B2194 γ-Oryzanol Inhibitor 99.66% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15229 Guadecitabine sodium Inhibitor 99.97% Phase 3
HY-112288 C188-9 Inhibitor 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135146 GSK-3484862 Inhibitor 99.95% Unkown
HY-13642 RG108 Inhibitor 99.93% Unkown
HY-13962 SGI-1027 Inhibitor 99.79% Unkown
HY-13420 Zebularine Inhibitor 99.49% Unkown
HY-B2230 Hinokitiol Inhibitor 99.90% Unkown
HY-101925 CM-272 Inhibitor 98.0% Unkown
HY-12746 DC-05 Inhibitor 99.04% Unkown
HY-139015 5-Aza-4'-thio-2'-deoxycytidine Inhibitor 99.89% Unkown
HY-117421A CM-579 trihydrochloride Inhibitor 97.00% Unkown
HY-12747 DC_517 Inhibitor 99.33% Unkown
HY-139664A (R)-GSK-3685032 Inhibitor 98.97% Unkown
HY-173002 MS9024 Degrader 99.83% Unkown
HY-117421 CM-579 Inhibitor / Unkown
HY-179409 MC3817 Inhibitor / Unkown
HY-19826 Isofistularin-3 Inhibitor / Unkown
HY-183852 GSK3830052 Inhibitor / Unkown
HY-182009 DNMT-IN-6 Inhibitor / Unkown
HY-179409A MC3817 free base Inhibitor / Unkown
HY-175988 DNMT/HDAC-IN-2 Inhibitor / Unkown
HY-172217 DNMT1-IN-5 Inhibitor / Unkown
HY-181955 MS1129 Degrader / Unkown
HY-182956 DNMT1 Degrader-1 Degrader / Unkown
HY-13642G RG108 (GMP) Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-135146G GSK-3484862 (GMP) Inhibitor / Unkown
HY-161694 DNMT1-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens DNMT1 NCBI NCBI:1786