2. Gene
  3. RGS18 - regulator of G protein signaling 18 Gene

RGS18 - regulator of G protein signaling 18 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RGS13

Gene ID: 64407 | Gene type: protein coding

About RGS18

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:192,158,462-192,185,815 (from NCBI)

This gene has 4 transcripts (splice variants), 124 orthologues and 23 paralogues. Broad expression in spleen (RPKM 9.4), appendix (RPKM 6.5) and 15 other tissues.

Summary

This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

RGS18 Products(1)

mRNA Protein Name
NM_130782.3 NP_570138.1 regulator of G-protein signaling 18

RGS18 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (86 - 201)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 18

regulator of G-protein signalling 13

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11912 RGS18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RGS18 RGD RGD:1306522
Felis catus RGS18 VGNC VGNC:107932
Canis familiaris RGS18 VGNC VGNC:45527
Mus musculus RGS18 MGD MGI:1927498
Macaca mulatta RGS18 VGNC VGNC:76732
Bos taurus RGS18 VGNC VGNC:33917