2. Gene
  3. VDR - vitamin D receptor Gene

VDR - vitamin D receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Macaca mulatta
Gene ID: 706964 | Gene type: protein coding

About VDR

Primary_assembly 11: 47,394,547-47,458,098 reverse strand.Mmul_10:CM014346.1

This gene has 4 transcripts (splice variants), 462 orthologues and 19 paralogues.

Summary

This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of Other metabolic pathways, such as those involved in immune response and Cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets in human. A recent study provided evidence for translation readthrough in this gene, and expression of a C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]

VDR Products(2)

mRNA Protein Name
NM_001364130.2 NP_001351059.2 vitamin D3 receptor isoform VDRx
NM_001364129.2 NP_001351058.2 vitamin D3 receptor isoform VDR

VDR Protein Structure

NR_DBD_VDR

NR_DBD_VDR: cd06955 (15 - 121)

NR_LBD_VDR

NR_LBD_VDR: cd06933 (123 - 425)

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  • 494 a.a.
Protein Preferred Names Protein Names

vitamin D3 receptor

vitamin D (1,25- dihydroxyvitamin D3) receptor

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10002 Calcitriol Agonist 99.94% Unkown
HY-32351 Calcifediol 99.94% Unkown
HY-10003 Alfacalcidol Activator 99.96% Unkown
HY-32339 Maxacalcitol Activator 99.71% Unkown
HY-32351A Calcifediol monohydrate 99.98% Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-32344 Inecalcitol 98.44% Phase 2
HY-32345 Elocalcitol 99.2% Phase 2
HY-14863 Lunacalcipol / Phase 2
HY-32351S3 Calcifediol-d9 / Phase 2
HY-B1844 Flucythrinate / Phase 1
Pre-clinical Phase
Bioactive Molecules (63)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147337 MeTC7 Antagonist 98.50% Unkown
HY-32343 Secalciferol Activator 99.85% Unkown
HY-12407 ZK168281 Antagonist 98.0% Unkown
HY-76814 Calcitriol-d6 Activator 99.27% Unkown
HY-32350 Ercalcitriol Activator 99.71% Unkown
HY-13332 Calcifediol-d6 Activator 99.09% Unkown
HY-12398 TEI-9647 Agonist 99.10% Unkown
HY-103053 PS121912 Inhibitor 96.40% Unkown
HY-10002A (1S)-Calcitriol 98.52% Unkown
HY-12398A TEI-9648 Inhibitor 99.24% Unkown
HY-77278 25-Hydroxytachysterol3 Agonist 98.07% Unkown
HY-12397 ZK159222 Antagonist 99.23% Unkown
HY-15329 Maxacalcitol-d6 Activator 96.03% Unkown
HY-32351S Calcifediol-d3 98.96% Unkown
HY-131492 Δ4-Dafachronic acid Ligand 96.93% Unkown
HY-RS15632 VDR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15265 Impurity F of Calcipotriol Activator 99.40% Unkown
HY-75035 Calcipotriol Impurity C Activator 99.11% Unkown
HY-N10508 Calcitroic acid Agonist 85.0% Unkown
HY-13294 Impurity C of Alfacalcidol Activator 99.81% Unkown
HY-15332 Alfacalcidol-d6 Activator 98.0% Unkown
HY-32351AS Calcifediol-d6 monohydrate 97.50% Unkown
HY-13293 Impurity C of Calcitriol Activator 99.84% Unkown
HY-131961 Triciferol 98.61% Unkown
HY-13292 Impurity B of Calcitriol Activator 98.04% Unkown
HY-154825 20-Hydroxyvitamin D3 ≥98.0% Unkown
HY-77274 Calcitriol Impurities D Activator 95.18% Unkown
HY-15264 MC 1046 Activator 91.48% Unkown
HY-114310 VDR agonist 1 / Unkown
HY-10002B (1R,5Z)-Calcitriol Control / Unkown
HY-119612 XCT0135908 / Unkown
HY-10002AS (1S)-Calcitriol-d3 / Unkown
HY-10002AS2 (1S)-Calcitriol-d6 / Unkown
HY-10002S1 Calcitriol-d3 / Unkown
HY-10002S2 Calcitriol-d9 / Unkown
HY-10003S Alfacalcidol-d7 Activator / Unkown
HY-117182 LG190178 / Unkown
HY-118970 LG190155 / Unkown
HY-131492S Δ4-Dafachronic Acid-d3 Ligand / Unkown
HY-149899 VDR agonist 2 Agonist / Unkown
HY-15364 19-nor-1α,25-Dihydroxyvitamin D3 Ligand / Unkown
HY-161778 ZG-126 / Unkown
HY-163947 UG-480 Modulator / Unkown
HY-166525S 24R-Calcipotriol-d4 Activator / Unkown
HY-170975 UG-650 Ligand / Unkown
HY-172087 VDR agonist 3 Agonist / Unkown
HY-178328 VDR agonist 4 / Unkown
HY-178336 AC-340 / Unkown
HY-179431 VDR ligand-1 Agonist / Unkown
HY-181486 VDR agonist 5 Agonist / Unkown
HY-182038 TGF-β1/Smad3-IN-2 / Unkown
HY-19380 Ro-65-2299 Agonist / Unkown
HY-32351AS1 Calcifediol-13C5 monohydrate / Unkown
HY-N10508S Calcitroic acid-13C / Unkown
HY-RS03451 CYP27B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15633 Vdr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15634 Vdr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10002S Calcitriol-13C3 Inhibitor 97.0% Unkown
HY-177795 5β-Cholanic acid-3,6-dione / Unkown
HY-180503 19-Nor-22-oxa-1a,25(OH)2-VD3 / Unkown
HY-32350S1 Ercalcitriol-d3 Activator / Unkown
HY-RS16287 Cyp27b1 Mouse Pre-designed siRNA Set A / Unkown
HY-107218 11-Hydroxysugiol Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens VDR NCBI NCBI:7421
Mus musculus VDR NCBI NCBI:22337